Abstract: TH-PO0574
Temporal Trends in Kidney Failure-Related Mortality in Postmenopausal Women in the United States, 1999-2024
Session Information
- CKD: From Global Burden to Precision Care - Epidemiology, Demographics, Geographies, and Risk Factors
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2201 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Premkumar, Chandra Rupini, Government Kilpauk Medical College and Hospital, Chennai, TN, India
- Mahrukh, Fnu, Faisalabad Medical University, Faisalabad, Punjab, Pakistan
- Chaudhary, Arishman Yasin, Faisalabad Medical University, Faisalabad, Punjab, Pakistan
- Attiq, Zainab, Faisalabad Medical University, Faisalabad, Punjab, Pakistan
- Rasheed Sohail, Shehryar, Jinnah Sindh Medical University, Karachi, Sindh, Pakistan
- Kashif, Shiza, Faisalabad Medical University, Faisalabad, Punjab, Pakistan
Background
Decline in glomerular filtration rate and vascular aging due to menopause is an important causal factor for renal failure (RF) in postmenopausal women. We undertook a retrospective study to stratify gender-specific nationwide mortality trends related to RF in postmenopausal women in the United States (U.S) from 1999-2024.
Methods
The CDC WONDER Multiple Cause-of-Death Public Use records from 1999-2024 were used to analyze mortality trends in post-menopausal women (≥55 years) using ICD-10 codes N17-N19 for RF. Age-adjusted mortality rates (AAMR) per 100,000 population were calculated. Annual percent change (APC) and average annual percent change (AAPC) with 95% confidence intervals were assessed using the Joinpoint Regression Program.
Results
A total of 2,499,585 deaths occurred due to RF in post-menopausal women. Overall AAMR significantly declined from 229.7 in 1999 to 199.2 in 2024 (AAPC: -0.49; 95% CI: -0.96 to 1.98). All age groups showed notable long-term declines; the 65-74 year age group (APC: -1.55; 95% CI: -2.20 to -0.84) showed the highest decrease. Hispanic/Latino women (AAPC: -2.12; 95% CI: -2.75 to -1.48) had a greater decline than non-Hispanic women (AAPC: -0.40; 95% CI: -0.88 to 0.30). Among non-Hispanic women, American-Indian or Alaskan Native women showed the greatest decline during the study period (AAPC: -2.24; 95% CI: -3.04 to -1.51). Regionally, the Northeast region had the greatest reduction in mortality (APC: -1.08; 95% CI: -1.64 to -0.26). Though mortality declined in both groups, it was more in urban areas (AAPC: -1.46%) than in rural areas (AAPC: -0.82%).
Conclusion
Demographic and regional disparities are a cause of concern; highlighting the need for early and prompt screening for all women over 40 with cardiovascular risks factors.