Abstract: FR-PO1040
Effects of High-Volume Hemodiafiltration and Expanded Hemodialysis on Body Composition and Nutritional Status
Session Information
- Hemodialysis: Clinical Challenges, Patient-Centered Outcomes, and Quality of Life
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Morales, Brenda, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico
- Ortuño Moreno, Nohelia María, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico
- Nieto-Velázquez, Goreti, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico
- Sanchez-Pozos, Katy, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico
- Garcia-Flores, Octavio Rene, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico
- Vasquez Jiménez, Enzo Christopher, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico
Background
Patients undergoing hemodialysis (HD) are at increased risk of morbidity and mortality, which is directly associated with poor nutritional status. Protein-energy wasting (PEW), defined as the loss of muscle mass and the body's energy reserves, is a common complication in patients receiving HD.
Online hemodiafiltration (OL-HDF) and HD with medium cut-off dialyzers (MCO-HD) provide efficient removal of uremic toxins, reduce inflammation, and help preserve lean body mass, thereby exerting beneficial effects on PEW.
We compared the effects of OL-HDF and MCO-HD on body composition and nutritional status in prevalent hemodialysis patients.
Methods
We conducted a prospective observational study in patients with chronic kidney disease (CKD) stage 5 according to Kidney Disease: Improving Global Outcomes, who were receiving post-dilution online hemodiafiltration (OL-HDF; n = 18) or medium cut-off hemodialysis (MCO-HD; n = 19). All patients were followed for 3 to 12 months and underwent multifrequency bioimpedance spectroscopy (BIS) measurements at baseline and at 3, 6, and 12 months. No nutritional supplements were prescribed.
BIS measurements included skeletal muscle mass (SM), lean mass (LM), fat mass (FM), phase angle (PA), and were performed at the beginning of a midweek hemodialysis (HD) session. Serum albumin, prealbumin, creatinine, total cholesterol, and triglycerides were measured at the same time points as the impedance assessments.
Results
After one year of follow-up, we did not observe a significant changes in body composition and bioimpedance parameters (SM, LM, FM, PA) in MCO-HD and OL-HDF, no changes were observed in biochemical nutritional parameters. (Table 1 - 2)
Conclusion
In patients treated with OL-HDF and MCO-HD, no differences in body composition were observed between groups, with no changes in SM, LT, FT or PA. Both treatments show a promising trend toward preserving body composition and preventing PEW.
Funding
- Government Support – Non-U.S.