Kidney Week

Abstract: INFO12-TH

The Indiana University O'Brien National Resource Center

Session Information

• Informational Posters - 1
  October 22, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Pathology and Lab Medicine

• No subcategory defined

Authors

• Poudel, Chetan, Indiana University School of Medicine, Indianapolis, Indiana, United States

Chetan Poudel, PhD

• Eadon, Michael T., Indiana University School of Medicine, Indianapolis, Indiana, United States

Michael T. Eadon, MD, FASN

• El-Achkar (Ashkar), Tarek M., Indiana University School of Medicine, Indianapolis, Indiana, United States

Tarek M. El-Achkar (Ashkar), MD, FASN

• Gulbronson, Connor J., Indiana University School of Medicine, Indianapolis, Indiana, United States

Connor J. Gulbronson, PhD

• Melo Ferreira, Ricardo, Indiana University School of Medicine, Indianapolis, Indiana, United States

Ricardo Melo Ferreira, PhD

• Liu, Jonathan T. C., University of Washington, Seattle, Washington, United States

Jonathan T. C. Liu, PhD

• Sutton, Timothy A., Indiana University School of Medicine, Indianapolis, Indiana, United States

Timothy A. Sutton, MD, PhD, FASN

• Vaughan, Joshua C., University of Washington, Seattle, Washington, United States

Joshua C. Vaughan, PhD

• Dagher, Pierre C., Indiana University School of Medicine, Indianapolis, Indiana, United States

Pierre C. Dagher, MD, FASN

Description

The Indiana University O'Brien National Resource Center (NRC) is part of the George M. O'Brien Kidney Resource Alliance (OKRA). Since its inception as an NIDDK-funded P50 Center in 2002, the mission of the IU O’Brien NRC has been to provide kidney researchers with effective access to advanced forms of microscopy. Over the past 20+ years, the IU O'Brien NRC has pioneered the development and dissemination of novel methods of multiphoton intravital microscopy, quantitative tissue cytometry, 3-dimensional fixed tissue imaging, spatial protein and transcriptomic imaging, and digital image analysis that have been applied in collaborative studies of kidney physiology and pathophysiology with investigators from around the world. Studies conducted with the IU O’Brien NRC have generated data used in over 200 publications and numerous grant applications that have helped launch the careers of a new generation of investigators. The goals of the IU O’Brien Center are to: 1. Provide quantitative intravital microscopy of mice and rats as a service to kidney researchers. 2. Provide quantitative, large-scale microscopy of the kidney as a service to kidney researchers through a combination of 3D confocal tissue cytometry, CODEX multiplexed cytometry, and single cell level spatial transcriptomics thus delivering uniquely comprehensive molecular characterizations. 3. Develop methods of tissue clearing, light-sheet microscopy, and image analysis to expand the scale of quantitative microscopy of the kidney. These services, designed to extend the scope and power of kidney research studies, are supported through an Opportunity Pool Program supported by the OKRA National Coordinating Center and a Pilot and Feasibility Program supported by Indiana University. The center also supports education through a unique student enrichment program and internationally-recognized advanced microscopy workshops.

Funding

• NIH/NIDDK