Kidney Week

Abstract: INFO18-FR

Pediatric Longitudinal Glomerular Disease: A PNRC Multi-Institutional Cohort Study (PLUGGED IN)

Session Information

• Informational Posters - 2
  October 23, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Pediatric Nephrology

• No subcategory defined

Authors

• Nester, Carla M., The University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, United States

Carla M. Nester, MD, MS, FASN

• Gaut, Joseph, Washington University in St Louis, St. Louis, Missouri, United States

Joseph Gaut, MD, PhD

• Amankwah, Ernest, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, United States

Ernest Amankwah, PhD

• Kouri, Anne, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States

Anne Kouri, MD

• Khalid, Myda, Indiana University School of Medicine, Indianapolis, Indiana, United States

Myda Khalid, MD, FASN

• Goldenberg, Neil A., Johns Hopkins All Children's Hospital, St. Petersburg, Florida, United States

Neil A. Goldenberg, MD, PhD

• Repay, Jaclyn, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, United States

Jaclyn Repay, MD

• Crumb, Teri L., Pediatric Nephrology Research Consortium, Baltimore, Ohio, United States

Teri L. Crumb, RN

• Dutcher, Amy, Pediatric Nephrology Research Consortium, Baltimore, Ohio, United States

Amy Dutcher, MS

• Smoyer, William E., The Research Institute at Nationwide Children's Hospital, Columbus, Oklahoma, United States

William E. Smoyer, MD

Description

The Pediatric Longitudinal Glomerular Disease: a PNRC Multi-Institutional Cohort Study (PLUGGED IN) has been developed by a multidisciplinary team of experts comprised of a steering committee with individuals with expertise in: Pediatric nephrology, a Renal pathology, Data Coordination, epidemiology, project management, clinical research, and pharmaceutical drug development. Together, the team developed a high-quality, integrated Clinical Coordinating Center (PNRC, Baltimore OH), Data Coordinating Center (Johns Hopkins All Children's, St. Petersburg, FL) and a Pathology Core Biorepository (Washington University School of Medicine, St. Louis, MO) paired with a lead physician (C. Nester, University of Iowa) and an initial 20-member U.S. site network to support execution of the study protocol. This retrospective/prospective observational study of pediatric patients with glomerular disease will investigate and determine important relationships among patient/disease characteristics, natural history, treatments, histopathologic response and outcomes, both across and within pre-specified broad glomerular disease cohorts, by means of multicenter collection, storage, and analysis of longitudinal clinical data and high-resolution digital pathology images (LM, IFM, EM). The database is 21 CFR Part 11 compliant and will lead to regulatory-grade data in support of academia-industry collaborations that foster real-world evidence to inform both the design and feasibility of future clinical trials and programs in novel therapeutics in pediatric glomerular disease.

Acknowledgment

We would like to acknowledge the PNRC and Corinna Bowers, Executive Director, for support in developing this study.

Funding

• Pediatric Nephrology Research Consortium and Novartis Pharmaceuticals.