Abstract: INFO09-TH
The Johns Hopkins O'Brien Center: Harnessing Basic, Clinical, and Translational Research to Advance Kidney Health
Session Information
- Informational Posters - 1
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Cardiovascular-Kidney-Metabolic Health
- No subcategory defined
Authors
- Crews, Deidra C., Johns Hopkins University, Baltimore, Maryland, United States
- Rebholz, Casey, Johns Hopkins University, Baltimore, Maryland, United States
- Pluznick, Jennifer L., Johns Hopkins University, Baltimore, Maryland, United States
- Welling, Paul A., Johns Hopkins University, Baltimore, Maryland, United States
- Coresh, Josef, New York University, New York, New York, United States
- Parikh, Chirag R., Johns Hopkins University, Baltimore, Maryland, United States
Description
The Johns Hopkins (JH) O’Brien Center to Advance Kidney Health is harnessing the collective expertise of basic, clinical and translational researchers at JH to serve as a national resource for investigators addressing the fundamental question of: what are the underlying mechanisms responsible for kidney diseases and how can they be mitigated?
Resources and services available to investigators include:
Clinical Science Dietary and Social Stressor Lab(C-DSSL) Services:
C-DSSL provides consultative services, validated protocols with well-established quality assurance/quality control procedures, and access to materials and equipment, with appropriate external resources. Resources and services include:
Clinical study design; dietary assessment and dietary data; feeding studies modeled on DASH trials; archived and completed studies; large longitudinal cohort study data; EMR registries; datasets with deep phenotyping (e.g. genomics, proteomics); stored biospecimen; prospective remnant sample collection; behavioral intervention studies; community based translational studies; biostatistical support; biomarker measurement; immunoassays; biorepository support; processing, allocating, short- and long-term sample storage.
Basic Science Dietary and Social Stressor Lab (B-DSSL) Services:
B-DSSL provides services and resources for preclinical research to determine the mechanistic underpinnings of kidney health stressors, using mice as a model system, including:
Study design; humanized mouse diet protocols; comprehensive mouse kidney phenotyping for diet and stress mechanisms; metabolic cage and clearance studies; GFR measurements; telemetric BP monitoring; isolated nephron segment ex vivo analysis; small sample RNAseq in isolated nephron segments; indirect calorimetry and lipid and carbohydrate metabolism phenotyping; Oxymax and CLAMS metabolic cages to monitor food intake, water intake, physical activity, metabolic rate (VO2), respiratory exchange ratio, and energy expenditure; immunological manifestations of stressors in the kidney; protocols to isolate and characterize kidney immune cells by flow cytometric analysis; microbiome; germ-free sample banks; and mouse biobank of dietary and social stress models.
A joint consultation service, and deliberate team approach melds the two laboratories, and creates an innovative bidirectional pipeline maximizing translation.
Acknowledgment
The Johns Hopkins O’Brien Center to Advance Kidney Health is supported by grant 1U54DK137331 from NIDDK/NIH.
Funding
- NIH/NIDDK