Basic/Clinical Science Session
Glom and Tell: Uncovering the Secrets of Glomerular Crosstalk
October 22, 2026 | 02:00 PM - 04:00 PM
Location: Mile High Ballroom 1A, Convention Center
Session Description
The glomerulus is a dynamic community in which podocytes, endothelial cells, mesangial cells, and immune cells constantly exchange signals that shape filtration and resilience. In diseases such as IgAN and diabetic kidney disease, this communication becomes distorted, amplifying injury and driving progression. This session explores how glomerular cells "talk," how these conversations break down, and how targeting maladaptive crosstalk may preserve kidney function.
Learning Objective(s)
- Describe the role of mesangial cells as integrative signaling hubs that coordinate communication among glomerular cell types in health and in disease
- Evaluate emerging evidence linking disrupted glomerular crosstalk to CKD progression across immune-mediated and nonimmune kidney diseases
- Explain the key mechanisms of glomerular crosstalk, including exosome-mediated signaling and complement activation, and how these pathways contribute to glomerular injury
- Identify knowledge gaps and future research directions in which targeting intercellular communication within the glomerulus may lead to novel treatments
Learning Pathway(s)
- Glomerular Diseases
- Kidney Biology and Physiology
Moderators
Presentations
- Mesangial Cells as Central Hubs for Glomerular Crosstalk
02:00 PM - 02:30 PM
- Clinical Implications for Glomerular Crosstalk in CKD
02:30 PM - 03:00 PM
- Role of Exosomes and Soluble Factors in Glomerular Crosstalk
03:00 PM - 03:30 PM
- Complement Crosstalk in the Glomeruli
03:30 PM - 04:00 PM