Translational Session
Navigating Complex Genomic Challenges in Kidney Transplantation, Including the Barbara T. Murphy, MB BAO BCh, Endowed Lectureship
October 23, 2026 | 02:00 PM - 04:00 PM
Location: Room 401, Convention Center
Session Description
This session highlights key challenges in kidney transplantation driven by the complexity of genetic and immune-mediated diseases. Topics include genotype-phenotype mismatch in transplant candidates, practical applications of genetic testing, and evaluation of living related donors when variants of uncertain significance are identified. Complement-mediated and recurrent glomerular diseases are discussed as examples of high-risk settings for recurrence. Emphasis is placed on strategies to optimize long-term transplant outcomes and address ongoing challenges in graft and patient survival in the era of precision medicine.
ASN gratefully acknowledges Verici Dx, Renalytix, and the American Society of Transplantation for support of the Murphy Endowed Lectureship.
Learning Objective(s)
- Identify and address genotype-phenotype mismatches in kidney transplant candidates and understand their implications for transplant eligibility and post-transplant outcomes
- Apply genetic testing strategies to evaluate kidney transplant candidates with unexplained or inherited kidney diseases, including interpretation of test results in clinical decision-making
- Interpret and manage phenotype-related variants of uncertain significance (VUS) in both recipients and living related donors, incorporating multidisciplinary input and strategies for variant reclassification
- Incorporate multiple risk factors, including genetic, immunological, clinical, and environmental, into the assessment of transplant recipients and donors, with a focus on strategies to optimize long-term graft survival and overall patient outcomes
Learning Pathway(s)
- Kidney Transplantation
- Genetic Diseases and Development
Moderators
Presentations
- Genotype-Phenotype Mismatch in Kidney Transplant Candidates
02:00 PM - 02:30 PM
- How to Approach a Living Related Donor of a Recipient with Phenotype-Related VUS
02:30 PM - 03:00 PM
- Complement-Mediated Kidney Diseases and Transplantation
03:00 PM - 03:30 PM
- Improving Long-Term Kidney Transplant Survival: Opportunities and Challenges: The Barbara T. Murphy, MB BAO BCh, Endowed Lectureship
03:30 PM - 04:00 PM