Basic/Clinical Science Session
Challenging the Podocyte-Centric Model: The Endothelium Strikes Back
October 23, 2026 | 02:00 PM - 04:00 PM
Location: Four Seasons Ballroom 1, Convention Center
Session Description
Despite recent breakthroughs in the field of podocytopathies, the mechanisms of podocyte injury remain incompletely understood. Most studies focus on podocyte biology; however, there is growing evidence of the endothelium's role in these conditions. Understanding the mechanisms by which the endothelium may alter podocyte health offers a unique opportunity to provide novel mechanistic insights and therapeutic targets.
Support for all sessions in the Glomerular Diseases Learning Pathway is provided by an educational grant from Vera Therapeutics, Inc.
Learning Objective(s)
- Describe the involvement of the endothelium in genetic forms of nephrotic syndrome with a focus on WT1 and its therapeutic implications
- Analyze the mechanisms of endothelial-podocyte crosstalk and therapeutic opportunities in Alport syndrome
- Articulate the importance of the glycocalyx and endothelial health in diabetic kidney disease
- Define the unexpected role of the endothelium in idiopathic nephrotic syndrome
Learning Pathway(s)
- Glomerular Diseases
- Pediatric Nephrology
Moderators
Presentations
- Targeting the Vasculature as a Therapy in WT1 Kidney Disease
02:00 PM - 02:30 PM
- Endothelial Glycocalyx as a Therapeutic Target in Diabetic Kidney Disease
02:30 PM - 03:00 PM
- Endothelial Injury Precedes Podocyte Damage in Experimental Alport Syndrome
03:00 PM - 03:30 PM
- Idiopathic Nephrotic Syndrome Inside-Out: Unveiling the Role of Glomerular Endothelium
03:30 PM - 04:00 PM