Basic/Clinical Science Session
Challenging the Podocyte-Centric Model: The Endothelium Strikes Back
October 23, 2026 | 02:00 PM - 04:00 PM
Location: Four Seasons Ballroom 1, Convention Center
Session Description
Despite recent breakthroughs in the field of podocytopathies, the mechanisms of podocyte injury remain incompletely understood. Most studies focus on podocyte biology; however, there is growing evidence of the endothelium's role in these conditions. Understanding the mechanisms by which the endothelium may alter podocyte health offers a unique opportunity to provide novel mechanistic insights and therapeutic targets.
Learning Objective(s)
- Describe the involvement of the endothelium in genetic forms of nephrotic syndrome with a focus on WT1 and its therapeutic implications
- Analyze the mechanisms of endothelial-podocyte crosstalk and therapeutic opportunities in Alport syndrome
- Articulate the importance of the glycocalyx and endothelial health in diabetic kidney disease
- Define the unexpected role of the endothelium in idiopathic nephrotic syndrome
Learning Pathway(s)
- Glomerular Diseases
- Pediatric Nephrology
Moderators
Presentations
- Targeting the Vasculature as a Therapy in WT1 Kidney Disease
02:00 PM - 02:30 PM
- Endothelial Glycocalyx as a Therapeutic Target in Diabetic Kidney Disease
02:30 PM - 03:00 PM
- Endothelial Injury Precedes Podocyte Damage in Experimental Alport Syndrome
03:00 PM - 03:30 PM
- Idiopathic Nephrotic Syndrome Inside-Out: Unveiling the Role of Glomerular Endothelium
03:30 PM - 04:00 PM