Basic/Clinical Science Session
Strengthening Kidney Resilience to AKI
October 22, 2026 | 02:00 PM - 04:00 PM
Location: Four Seasons Ballroom 2, Convention Center
Session Description
Currently, no effective therapies robustly enhance the kidneys' resilience to AKI, a critical unmet clinical need. This session explores recently identified cellular and molecular processes that underpin renal homeostasis and the kidneys' resilience to injury and their role in progression to CKD. Additionally, an innovative genetic strategy is presented to rigorously dissect the therapeutic potential of cell type-specific, resilience-augmenting interventions.
Learning Objective(s)
- Explain how sexual dimorphism and transcription factor biology can be used as a biological lens to reveal fundamental mechanisms and therapeutic strategies that strengthen kidney resilience and subsequent progression of AKI to CKD
- Describe how mitochondrial stress responses and heteroplasmy dynamics influence resilience following AKI
- Explain how an innovative, cell type-specific genetic strategy can be used to rigorously dissect and validate candidate mechanisms that enhance kidney resilience
Learning Pathway(s)
- AKI and Critical Care
Moderators
Presentations
- Role of Estrogen in Kidney Resilience Through Ferroptosis Defense
02:00 PM - 02:30 PM
- Heteroplasmic Mitochondrial Variants and Kidney Resilience
02:30 PM - 03:00 PM
- HNF1B Maintains Kidney Resilience and Integrates Signals in a Feed-Forward Loop Driving Kidney Disease Progression
03:00 PM - 03:30 PM
- Activating Female-Biased Molecular Programs in Male Proximal Tubules
03:30 PM - 04:00 PM