Oral Abstract Session
Genetic Diseases with a Focus on ADPKD Mechanisms, Models, and Medicines
October 22, 2026 | 04:30 PM - 06:00 PM
Location: Mile High Ballroom 4D, Convention Center
Session Description
Oral Abstract Session
Learning Pathway(s)
- Genetic Diseases and Development
Moderators
Presentations
Monoallelic Loss of Human PKD1 Causes ADPKD in a Fully Humanized Mouse Model
Spatial Transcriptomics Reveal Progressive Tubular-to-Cyst Transitions and Conserved Transcription Factor Networks in Mouse and Human ADPKD
Rac1 Restrains the Actin-Myosin Cytoskeleton to Enable Mechanosensing and Prevent Cystic Transformation of Postnatal Kidneys
Mitigation of Cystogenesis in ADPKD: Role of PC1-interacting IP1 Deficiency in Modulation of LC3-Dependent Autophagy
Collecting Duct-Targeted Lipid Nanoparticles Deliver Pkd2 mRNA to Attenuate ADPKD
A Phase 1 Study of PYC-003, a Peptide-Oligonucleotide Conjugate That Increases PC1 Expression in Patients with ADPKD
Developing Adeno-Associated Virus (AAV)-Mediated Gene Replacement Therapy in an Hnf1b Knockout Mouse Model
A Live Cell In Vitro System to Assess Functional Rescue of Polycystin Missense Variants
Antisense Oligotherapy Against Metabolic Sensor O-GlcNAc Transferase Mitigates PKD in Mice