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Abstract: FR-PO468

Comparison of Renal Outcomes Between Diffuse and Nodular Diabetic Nephropathy: A Meta-Analysis

Session Information

Category: Diabetic Kidney Disease

  • 602 Diabetic Kidney Disease: Clinical


  • Feng, Qiqi, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
  • Rao, Jialing, The Third Affiliated Hospital of Sun Yet-sen University, Guangzhou, China
  • Lai, Weiyan, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

The diffuse (DIF) type and the nodular (NOD) type of glomerulosclerosis have long been recognized as the pathological characteristics of diabetic nephropathy (DN). However, the relationship between pathological changes and renal outcomes is not fully elucidated so far. The present meta-analysis was designed to compare the renal outcomes between the two pathological types of DN.


We reviewed relevant studies that compared the renal outcomes between DIF and NOD in Medline, Embase, Cochrane Library, CNKI and other sources from 1950 to 2015.


Of 3615 citations identified, only four retrospective cohort studies involving 596 patients were included in the meta-analysis. Pooled analysis of relative risk (RR) in the fixed-effects model showed that NOD had higher risk for developing ESRD than DIF did (RR 1.86, 95%CI 1.28-2.70, P = 0.001, P for heterogeneity = 0.12, I2 = 48%). The sensitivity analysis showed that the heterogeneity among studies was decreased when studies with type 1 diabetic patients were excluded (P for heterogeneity = 0.34, I2 = 0%).


The present meta-analysis revealed that renal outcomes were closely related to pathological changes of DN, and NOD had higher risk for developing ESRD than DIF.

Fig. 1 Comparison of renal outcomes between the diffuse (DIF) type of diabetic nephropathy and the nodular (NOD) type