Abstract: FR-PO468
Comparison of Renal Outcomes Between Diffuse and Nodular Diabetic Nephropathy: A Meta-Analysis
Session Information
- Diabetic Kidney Disease: Clinical - I
October 26, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Diabetic Kidney Disease
- 602 Diabetic Kidney Disease: Clinical
Authors
- Feng, Qiqi, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Rao, Jialing, The Third Affiliated Hospital of Sun Yet-sen University, Guangzhou, China
- Lai, Weiyan, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Background
The diffuse (DIF) type and the nodular (NOD) type of glomerulosclerosis have long been recognized as the pathological characteristics of diabetic nephropathy (DN). However, the relationship between pathological changes and renal outcomes is not fully elucidated so far. The present meta-analysis was designed to compare the renal outcomes between the two pathological types of DN.
Methods
We reviewed relevant studies that compared the renal outcomes between DIF and NOD in Medline, Embase, Cochrane Library, CNKI and other sources from 1950 to 2015.
Results
Of 3615 citations identified, only four retrospective cohort studies involving 596 patients were included in the meta-analysis. Pooled analysis of relative risk (RR) in the fixed-effects model showed that NOD had higher risk for developing ESRD than DIF did (RR 1.86, 95%CI 1.28-2.70, P = 0.001, P for heterogeneity = 0.12, I2 = 48%). The sensitivity analysis showed that the heterogeneity among studies was decreased when studies with type 1 diabetic patients were excluded (P for heterogeneity = 0.34, I2 = 0%).
Conclusion
The present meta-analysis revealed that renal outcomes were closely related to pathological changes of DN, and NOD had higher risk for developing ESRD than DIF.
Fig. 1 Comparison of renal outcomes between the diffuse (DIF) type of diabetic nephropathy and the nodular (NOD) type