Kidney Week

Abstract: FR-PO897

Glomerular Neovascularization in Renal Allograft: Clinical and Pathological Significance

Session Information

• Transplantation: Translational and Transplant Pathology
  October 26, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Transplantation

• 1802 Transplantation: Clinical

Authors

• Sawada, Anri, Tokyo women's medical university, Tokyo----, Japan

Anri Sawada,

• Okumi, Masayoshi, Tokyo Women's Medical University, Shinjuku-ku, TOKYO, Japan

Masayoshi Okumi,

• Unagami, Kohei, Tokyo Women's Medical University, Shinjuku-ku, TOKYO, Japan

Kohei Unagami,

• Fuchinoue, Shohei, Tokyo Women's Medical University, Shinjuku-ku, TOKYO, Japan

Shohei Fuchinoue,

• Taneda, Sekiko, Tokyo womens'' medical university, Tokyo, Japan

Sekiko Taneda,

• Ishida, Hideki, Tokyo Women''s Medical University, Tokyo, Japan

Hideki Ishida,

• Hattori, Motoshi, Tokyo Women's Medical University, Shinjuku-ku, TOKYO, Japan

Motoshi Hattori,

• Tanabe, Kazunari, Tokyo Women's Medical University, Shinjuku-ku, TOKYO, Japan

Kazunari Tanabe,

• Shimizu, Akira, Nippion Medical School, Tokyo, Japan

Akira Shimizu,

• Koike, Junki, St.Marianna University, Kawasaki, kanagawa, Japan

Junki Koike,

• Nagashima, Yoji, TTokyo Women''s Medical University, Tokyo, Japan

Yoji Nagashima,

• Nitta, Kosaku, Tokyo Women's Medical University, Shinjuku-ku, TOKYO, Japan

Kosaku Nitta,

Background

An extra efferent arteriole is often observed in the glomerular vascular pole. This morphological change is referred to as polar vasculosis (PV). PV has been associated with glomerular hypertrophy and is considered as a sign for detecting early recurrent diabetic nephropathy after renal allograft. We have often noted PV even in cases without diabetic nephropathy after renal allograft; however, its significance remains uncertain. In the present study, we examined the clinical and pathological significance of PV in renal allograft.

Methods

This study included 9,004 renal biopsy specimens obtained from January 2007 to December 2017 at the Tokyo Women’s Medical University.

Results

PV was identified in 186 biopsies obtained from 165 patients. We excluded 44 biopsies from 36 patients because of transmitted PV, which was detected in pre-transplantation biopsy. We identified 142 biopsies from 129 patients as the PV group. In addition, we identified 130 control renal allograft recipients who were matched according to their age and post-transplantation period. We obtained the clinical information of 48 and 116 patients in the PV and control groups, respectively. In the PV group, the mean age was 49.0 ± 14.0 years, and the mean post-transplantation period was 1850.1 ± 2235.7 days. In the pathological findings, a significant correlation was observed among glomerulomegaly, focal segmental glomerulosclerosis lesion, mm score, ah score, and aah score in Banff score (P < 0.05). The clinical findings revealed a significant correlation between the tacrolimus trough level at two weeks post-transplantation and the systolic blood pressure (P < 0.05).

Conclusion

This findings of this study indicated that polar vasculosis is associated with calcineurin inhibitor toxicity along with glomerular hypertrophy.