Kidney Week

Abstract: TH-PO445

Arterial Stiffness and Kidney Function Decline in SPRINT

Session Information

• Hypertension and CVD: Epidemiology, Risk Factors, Prevention
  October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Hypertension and CVD

• 1401 Hypertension and CVD: Epidemiology, Risk Factors, and Prevention

Authors

• Nowak, Kristen L., University of Colorado Denver: Anschutz Medical Campus, Aurora, Colorado, United States

Kristen L. Nowak,

• Jovanovich, Anna Jeanette, University of Colorado Denver: Anschutz Medical Campus, Aurora, Colorado, United States

Anna Jeanette Jovanovich,

• You, Zhiying, University of Colorado Denver: Anschutz Medical Campus, Aurora, Colorado, United States

Zhiying You,

• Chonchol, Michel, University of Colorado Denver: Anschutz Medical Campus, Aurora, Colorado, United States

Michel Chonchol,

• Supiano, Mark A., University of Utah and VA Salt Lake City, Salt Lake City, Utah, United States

Mark A. Supiano,

Background

Arterial stiffness increases with advancing age and chronic kidney disease. Arterial stiffness may contribute to a decline in kidney function; however, evidence is inconsistent. We hypothesized that greater baseline arterial stiffness was independently associated with rapid decline in kidney function over the longitudinal follow-up period in the Systolic Blood Pressure Intervention Trial (SPRINT).

Methods

538 adults who participated in an ancillary study of SPRINT which measured arterial stiffness (aortic pulse-wave velocity [aPWV]) were included in this analysis. Multivariable logistic regression was used to examine the association between baseline aPWV and rapid decline in kidney function (estimated glomerular filtration [eGFR] decline >3 ml/min/1.73m²/yr) over the follow-up period (median of 3.7 yrs).

Results

Mean age was 72+3 years with a mean baseline aPWV of 10.6+2.6 m/sec and eGFR of 67+21 ml/min/1.73 m². 109 participants had rapid decline in renal function over the follow-up period. After adjustment demographics, randomization group, co-morbid conditions, smoking, body-mass index, estimated glomerular filtration rate, urinary albumin to creatinine ratio, antihypertensive medications, systolic blood pressure, and heart rate, baseline aPWV was not associated with increased odds of rapid decline in kidney function (OR: 1.03, 95% CI: 0.93-1.13 per unit increase in aPWV). In the fully adjusted model, baseline aPWV above the median also did not associate with rapid decline in kidney function (OR: 0.92, 95% CI: 0.56-1.51).

Conclusion

Among adults at high risk for cardiovascular events, greater arterial stiffness is not associated with rapid decline in kidney function.

Funding

• NIDDK Support