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Abstract: SA-PO718

Differential Impact of Self-Reported and eGFR-Based CKD on the Outcomes of Community-Dwelling Elderly

Session Information

  • Geriatric Nephrology
    October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Geriatric Nephrology

  • 1100 Geriatric Nephrology

Author

  • Chao, Chia-Ter, National Taiwan University Hospital BeiHu branch, Taipei City, Taiwan

Group or Team Name

  • COhort of GEriatric Nephrology in NTUH (COGENT study group)
Background

Awareness of CKD has been low among affected patients, particularly elderly. However, whether such awareness is synonymous with the presence of laboratory-diagnosed CKD is currently unclear.

Methods

We retrospectively enrolled 2932 community-dwelling old adults (≥65 years) who received health examinations between 2013 and 2016 from a regional hospital. Clinical information and geriatric syndromes including depression, cognitive impairment, fall, quality of life, and visual disturbance were evaluated during medical interview. We compared differences in clinical features between those with and without self-reported or estimated glomerular filtration rate (eGFR)-based CKD and investigated their influences and interactions on the risk of CKD complications and geriatric syndromes.

Results

Among 2932 elderly (mean 73.4 years), 93 (3%) reported having CKD by history, while 585 (20%) had an eGFR <60 mL/min/1.73m2 persisted over 3 months. The prevalence of body mass index, waist circumference, and the incidence of fall differed only between those with and without eGFR-based CKD, but not self-reported CKD. A synergistic effect was found between self-reported and eGFR-based CKD regarding the CKD complication severity, including malnutrition (albumin), anemia (hemoglobin), dyslipidemia (serum cholesterol), and geriatric syndromes (cognitive and quality of life impairment) (Fig 1). Those with self-reported without eGFR-based CKD had specific features differing from others (Fig 2). Multivariate regression analyses showed that self-reported CKD exhibited better predictive efficacy for lower serum albumin and hemoglobin than eGFR-based CKD, while the latter outperformed the former for predicting lower serum cholesterol and a higher risk of cognitive impairment.

Conclusion

Among older adults, self-reported CKD may not be a surrogate for laboratory-diagnosed CKD and has an independent effect on CKD-related complications.

Fig 1

Fig 2

Funding

  • Clinical Revenue Support