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Kidney Week

Abstract: SA-PO1040

Effect of Low-Protein Rice on Progression of CKD

Session Information

Category: CKD (Non-Dialysis)

  • 1902 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Authors

  • Chailimpamontree, Worawon, Bhumibol Adulyadej hospital, Bangkok, Thailand
  • Thananphuwasit, Anupong, Bhumibol Adulyadej hospital, Bangkok, Thailand
  • Gojaseni, Pongsathorn, Bhumibol Adulyadej hospital, Bangkok, Thailand
  • Chittinandana, Anutra, Bhumibol Adulyadej hospital, Bangkok, Thailand
Background

CKD is a worldwide public health problem. Protein restriction is effective in slowing the progression of kidney disease. Rice is the main staple foods in Thailand. However, besides carbohydrates, rice also consists of low biological value proteins. Since it is not easy to control dietary protein intake in patients who eat normal-protein rice(protein content 8g/rice100g),low protein rice(protein content 1.6g/rice100g) has been developed to counter these problems. As it is, the data on low-protein rice’s effect on CKD progression is limited. This pilot study was done to determine the impact of low-protein rice on CKD progression.

Methods

This involved a controlled before-and-after study in patients with stage 3-4 CKD who had protein intake of> 0.8 g/kg/day. The study covered a total duration of 6 months: the first 3 months when patients ate normal-protein riceand the second 3 months when they ate low protein-rice. All patients received multidisciplinary team care and were advised to have 0.6-0.8 gram/kg/day of protein intake along the study.

Results

32 patients were included in this study. Majority of patients were male (56.3%): 62.5% have diabetes and 81.3%have CKD stage 4. Mean age of patients is 55.9 years. After eating low-protein rice for 3 months, we noted that the GFR increased from baseline by 2.0 ± 3.1 ml/min/1.73m2(P=0.031). The nPNA reduced from baseline by 0.1 g/kg (95%CI: -0.2, 0.1, P = 0.04).In addition, eating low-protein rice significantly decreased waist circumference.

Conclusion

Low protein-rice has an impact on improving kidney function. It is also helping patients controlling dietary protein intake and improved there's body composition. Further studies are required before applied to all CKD patients who eating rice as a main cultural cuisine.