Kidney Week

Abstract: TH-PO1066

Recent Prevalence and Characteristic of CKD Including Diabetic Kidney Disease Among Participants of Nationwide Health Check Program in Japan

Session Information

• CKD: Epidemiology, Risk Factors, Prevention - I
  October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 1901 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Asahi, Koichi, Fukushima Medical University, Fukushima, Japan

Koichi Asahi,

• Nagai, Kei, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

Kei Nagai,

• Tsunoda, Ryouya, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

Ryouya Tsunoda,

• Tsuruya, Kazuhiko, Nara Medical University, Kashihara, Japan

Kazuhiko Tsuruya,

• Iseki, Kunitoshi, Nakamura Clinic, Urasoe, Japan

Kunitoshi Iseki,

• Yamagata, Kunihiro, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

Kunihiro Yamagata,

Background

Diabetic kidney disease (DKD) is most important target of intervention for improvement of outcome of chronic kidney disease (CKD). Recent prevalence and characteristic of CKD including DKD among a Japanese general population are not fully elucidated.

Methods

Subjects were residents from 27 of the 47 prefectures in Japan who enrolled in national health insurance and participated in annual health check program including a CKD screening in 2015 (n=1,059,888; age, 40-74 years; male, 42.8%; diabetics [HbA1c≥6.5% or undergoing pharmacotherapy for diabetes], 12.3%). CKD was defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m² or dipstick albuminuria ≥1+. CKD comorbid with diabetics was regarded as DKD．Cross-sectional analysis of the distribution of GFR (G) and albuminuria (A) categories by sex/age group among participants were performed. (A1: <1+, A2: 1+, A3: ≥2+ by dipstick)

Results

The distribution of each G and A categories are summarized in Table. Thus, in this screened population, the crude prevalence of CKD was 19.7%, and those with reduced renal function classified between G3-5 accounted for 16.6%. Among diabetics, the crude prevalence of CKD was 27.7% and was higher than in non-diabetics across all age groups with tendency that became noteworthy in younger population. (Figure 1) As for the distribution of G and A category among DKD, G3a and A1 were most prevalent in the age groups ≥65 years. (Figure 2)

Conclusion

Recent prevalence of G3-5 might slightly increase compared with similar cross-sectional analysis in 2008 (Iseki K, et al. Clin Exp Nephrol 16: 244-249, 2012). The overwhelming majority of aged DKD remain mild to moderate renal dysfunction without albuminuria. Therefore, it is important for screened DKD that strategic allocation of health resources according to age and individual risk would be established.

Funding

• Government Support - Non-U.S.