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Abstract: FR-PO738

Hemodialysis (HD) Using Molecular Hydrogen-Enriched Dialysate Generates Greater Amount of Exhaled Hydrogen Than Conventional HD, Decreases Plasma Glucose, and Increases Serum LDL-C in One Session

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Iwatani, Hirotsugu, Osaka National Hospital, Osaka, Japan
  • Asahina, Yuta, Osaka National Hospital, Osaka, Japan
  • Koizumi, Shintaro, Osaka National Hospital, Osaka, Japan
  • Yamato, Masafumi, Osaka National Hospital, Osaka, Japan
Background

Novel hemodialysis using molecular hydrogen-enriched dialysate (Hydrogen HD) is reported to improve the prognosis of patients on chronic dialysis. To investigate whether or not this effect is derived from the hydrogen infused through dialysate, we aimed to investigate the difference of exhaled hydrogen concentration between novel Hydrogen HD and conventional HD. We also investigated the effect of Hydrogen HD on glucose and lipid metabolism.

Methods

We investigated the exhaled hydrogen concentration (ppm) of patients undergoing Hydrogen HD and conventional HD and compared the concentrations between the two groups. The subjects are eight adult HD inpatients in our hospital that gave written informed consent to go through Hydrogen HD and conventional HD. Exhaled hydrogen concentration were monitored at 0h, 0.5h, 1h, 2h after the start of HD, at the end of HD, and 0.5h after the end of HD (6 points). Exhaled hydrogen was calculated as AUC. Plasma glucose and lipid profile were also investigated before and after the each session of HD. Statistical analyses were performed by Wilcoxon signed rank test using JMP. The ethics committee in our hospital approved this study.

Results

The patients’ characteristics were as follows; age 74 (63-79) y.o., sex F/M 3/5. Total exhaled hydrogen in Hydrogen HD was 502 (261-1541) ppm*hour and that in conventional HD was 45 (11-149) ppm*hour (p=0.0078). Serum LDL-C changes from 75 (39-102) to 78 (43-105) in Hydrogen HD significantly (p= 0.0156) and from 79 (45-105) to 78 (49-103) in conventional HD (n.s.). Plasma glucose changes from 142 (111-168) to 117 (99-144) in Hydrogen HD significantly (p=0.0078) and from 144 (111-184) to 129 (105-166) in conventional HD (n.s.).

Conclusion

Exhaled hydrogen in hemodialysis treatment using molecular hydrogen-enriched dialysate is significantly greater in amount than that in conventional HD. Overflowed molecular hydrogen from exhaled gas is the clue that the beneficial effect of this novel HD is based on the infused molecular hydrogen from dialysate. Hydrogen HD decreases plasma glucose and increases serum LDL-C in one session.

Funding

  • Commercial Support