Abstract: TH-PO897
Oral Administration of Paramylon, a β-1,3-D-Glucan Isolated from Euglena gracilis Z Protects Against Renal Damage in CKD Rats
Session Information
- Molecular Mechanisms of CKD - I
October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 1903 CKD (Non-Dialysis): Mechanisms
Authors
- Nagayama, Yoshikuni, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan
- Yamano, Mizuki, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan
- Nakashima, Ayaka, euglena Co.,Ltd., Tokyo, Japan
- Suzuki, Kengo, euglena Co.,Ltd., Tokyo, Japan
- Matsui, Katsuyuki, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan
Background
Paramylon is a β-1,3-D-Glucan that is stored by Euglena gracilis Z and a large porous molecule and plays various roles in chemical storage, ion exchange, and as a molecular sieve. It has been demonstrated to have anti-allergy effects and enhance immunological functions. Now available treatments are limited in the progression of chronic kidney disease (CKD). The aim of this study is to investigate the effect of Paramylon in CKD rats.
Methods
CKD was induced in 8-week-old male Wistar rat by 5/6 nephrectomy (Nx). A normal diet was given for 8 weeks in Sham control or in Nx rats. A diet containing 5% paramylon (PAR) obtained from euglena Co., Ltd was given for 8 weeks in Nx + PAR rats.
Results
There were no significant differences of the body weight, diet intake, and water intake between Nx and Nx + PAR groups. Increases in serum urea nitrogen and urinary protein excretion in Nx were significantly suppressed in Nx + PAR. Nx + PAR also showed histologically milder disease when compared to Nx (glomerular sclerotic score 1.8±0.4 vs. 0.9±0.2, means±SEM, p<0.05; tubular injury score 2.8±0.3 vs. 1.0±0.2, p<0.05; fibrosis area (%) 4.0±0.7 vs. 2.7±0.5, p=0.15; the number of interstitial PCNA-positive cells per high-power field 72±10 vs. 36±6.5, p<0.05).
Conclusion
Our data suggest that Paramylon may be a novel compound against the progression of renal damage in CKD rats.