Kidney Week

Abstract: TH-PO466

α-Adducin Polymorphism’s Influence on Ischemic Strokes

Session Information

• Hypertension and CVD: Epidemiology, Risk Factors, Prevention
  October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Hypertension and CVD

• 1401 Hypertension and CVD: Epidemiology, Risk Factors, and Prevention

Authors

• Casanova, Paola, San Raffaele Scientific Institute, Milan, Milano, Italy

Paola Casanova,

• Merlino, Lino, San Raffaele Scientific Institute, Milan, Milano, Italy

Lino Merlino,

• Lanzani, Chiara, San Raffaele Scientific Institute, Milan, Milano, Italy

Chiara Lanzani,

• Zagato, Laura, San Raffaele Scientific Institute, Milan, Milano, Italy

Laura Zagato,

• Delli carpini, Simona, San Raffaele Scientific Institute, Milan, Milano, Italy

Simona Delli carpini,

• Messaggio, Elisabetta, San Raffaele Scientific Institute, Milan, Milano, Italy

Elisabetta Messaggio,

• Manunta, Paolo, San Raffaele Scientific Institute, Milan, Milano, Italy

Paolo Manunta,

• Simonini, Marco, San Raffaele Scientific Institute, Milan, Milano, Italy

Marco Simonini,

Background

rs4961 Gly460Trp variant of the alpha Adducin gene (ADD1) has been associated with renal sodium retention and salt sensitive hypertension. Previous studies indicated ADD1 Gly460Trp as associated to higher risk of cardiovascular diseases. The aim of this study is to assess whether there is a correlation between this ADD1 variant and the development of ischemic strokes

Methods

212 patients with ischemic stroke (IS) were recruited from San Raffaele Hospital in Milan and divided into four categories according to Oxford Classification. These patients were compared to a cohort of elder general population (EGP, 128 patients) and a cohort of hypertensive patients (HYP, 2404 patients), both with no history of strokes.

Results

In IS group mean age at strokes’ diagnosis was 72.34±11.9, 61% men, 39% women. The incidence of CV risk factors was: hypertension 66%, diabetes 22%, hypercholesterolemia 40% and hypertriglyceridemia 13%, previous stroke 14%, CKD 16%. Two comparable populations were selected with similar age (71.28±6.9 years for EGP) and with the same incidence of risk factors (for HYP population). Notably, the presence of subjects homozygous for ADD1 mutated allele (rs4961 TrpTrp) is more than double in patients bearing ischemic stroke than in the two others (6.1% IS vs. 2.3% EP, p=0.049; 6.1% IS vs. 2.2 HYP, p = 0.009; fig.1). There was no statistically difference among the various types of stroke.

Conclusion

These data suggest a correlation between mutated alpha-Adducin and the increased incidence of all types of ischemic stroke. No correlation was found with the other hypertension-related genes analysed (as ADD2, ADD3).
rs4961 alpha-Adducin polymorphism should be considered as an independent risk factor for ischemic strokes, even if these events donot appear directly linked to hypertension. Finally, alpha-Adducin polymorphism itself might be a candidate gene in the pathogenesis of stroke.