ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: SA-PO466

AKI Biomarkers Associate with Risk for Diabetic Nephropathy

Session Information

  • Pediatric Nephrology - II
    October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Pediatric Nephrology

  • 1600 Pediatric Nephrology

Authors

  • Kremsdorf, Robin Amy, Brown University, Providence, Rhode Island, United States
  • Topor, Lisa Swartz, Brown University, Providence, Rhode Island, United States
Background

Children with diabetes mellitus (DM) are at significant risk to develop diabetic nephropathy. While conventional therapies (glycemic control, treating microalbuminuria with ACE inhibition) can reduce this risk, other determinants of renal outcomes in children with DM are poorly understood. We measured urine biomarkers of acute renal tubular injury in children and young adults with DM to identify if these biomarkers correlate with traditional renal risk factors.

Methods

Subjects between the ages of 10-21 years were recruited from DM clinics. Inclusion criteria included Type 1 DM for 3 years or longer or Type 2 DM for any duration. Clinical data, blood samples, and urine samples were obtained. The urine biomarkers neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule 1 (KIM1), and liver fatty-acid binding protein (L-FABP) were measured. Linear regression was used to analyze the relationship between each biomarker and clinical parameters (age, duration of diabetes, gender, hemoglobin A1c, presence of microalbuminuria > 30 mg/g).

Results

Of 155 subjects, 64 (41%) were female, 109 (70%) where white, and 129 (83%) had Type 1 DM. Mean (standard deviation, SD) age was 15.5 (2.7) years. Mean (SD) hemoglobin A1c was 9.1% (1.7) in those with Type 1 DM and 7.9% (2.6) among those with Type 2 DM. NGAL was associated with female gender (43 ng/mL higher in females), higher KIM-1 associated with microalbuminuria (6047 pg/mL higher in the presence of microalbuminuria), and L-FABP associated with hemoglobin A1c (0.23 pg/mL lower for each 1% increase of HgbA1c). These associations persisted when the analysis was restricted to subjects with Type 1 DM.

Conclusion

Amongst children and young adults with DM, acute kidney injury biomarkers have baseline associations with known risk factors for diabetic nephropathy. It will be important to determine if these biomarkers are associated with clinically relevant endpoints in the future.

Funding

  • Private Foundation Support