Abstract: FR-PO832
Impact of Transferrin Saturation on All-Cause Mortality in Patients on Maintenance Hemodialysis
Session Information
- Dialysis: Hospitalization and Mortality
October 26, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 702 Dialysis: Home Hemodialysis
Author
- Nitta, Kosaku, Tokyo Women's Medical University, Shinjuku-ku, ToKyo, Japan
Background
To evaluate iron status, transferrin saturation (TSAT) and serum ferritin levels are commonly used. TSAT provides an assessment of how much transferrin has bound iron, whereas serum ferritin is a marker used to reflect body iron storage. Our aim was to evaluate the prognostic importance of TSAT in Japanese patients on maintenance hemodialysis (MHD).
Methods
A total of 398 MHD patients were recruited and divided into 3 groups according to baseline TSAT of <20%, 20–40%, and >40%. The mean duration of the study was 52.2 ± 16.3 months. The primary endpoint was all-cause mortality, and the secondary endpoint was cardiovascular (CV) mortality.
Results
A total of 130 patients died during a mean follow-up duration of 52.2 ± 16.3 months. There were no differences in the proportion of patients on erythropoiesis-stimulating agents or iron supplements among the 3 groups. During a mean follow-up duration of 52.2 ±1 6.3 months, 130 patients died of CV causes (n = 63, (15.8%) and infection (n = 47, 11.8%). Compared with the reference group (TSAT 20–40%), patients with TSAT <20% had significantly higher all-cause mortality rates (6.44 vs. 9.55 events per 100 patient-year, p = 0.0452). Kaplan-Meier analysis also showed that all-cause mortality rates were significantly higher in patients with TSAT <20% compared to the other two groups (p =0.0353).
Conclusion
Low TSAT was a significant independent risk factor for all-cause mortality in a cohort of Japanese MHD patients. These findings suggested that the adverse clinical outcomes in patients with low TSAT can be partly attributed to iron-deficiency anemia.