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Abstract: SA-PO1068

The Impact of Pre-ESRD Testosterone Level upon Post-ESRD Mortality Among US Male Veterans: A Transition of Care in CKD Study

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1302 Health Maintenance, Nutrition, and Metabolism: Clinical

Authors

  • Hsiung, Jui-Ting, University of California, Irvine, Orange, California, United States
  • Streja, Elani, Harold Simmons Center for Kidney Disease Research and Epidemiology, Orange, California, United States
  • You, Amy Seung, University of California, Irvine, Orange, California, United States
  • Potukuchi, Praveen Kumar, University of Tennessee Health Science Center, Memphis, Tennessee, United States
  • Soohoo, Melissa, University of California at Irvine, Orange, California, United States
  • Nguyen, Danh V., University of California, Irvine, Orange, California, United States
  • Amin, Alpesh, UC Irvine, Orange, California, United States
  • Sim, John J., Kaiser Permanente Southern California, Los Angeles, California, United States
  • Kovesdy, Csaba P., University of Tennessee Health Science Center, Memphis, Tennessee, United States
  • Kalantar-Zadeh, Kamyar, University of California Irvine, School of Medicine, Orange, California, United States
  • Rhee, Connie, University of California Irvine, Huntington Beach, California, United States
Background

Testosterone deficiency is a common endocrine complication in the elderly male population, with a disproportionately high prevalence observed in those with chronic kidney disease (CKD). While lower circulating levels of testosterone have been linked with higher risk of cardiovascular disease and death in the general population, little is known about the impact of testosterone deficiency upon the health and survival of non-dialysis dependent (NDD) CKD patients transitioning to end-stage renal disease (ESRD).

Methods

Among a national cohort of male US veterans with NDD-CKD transitioning to ESRD over 2007-15, we examined the association of total testosterone levels averaged over the two-year pre-ESRD prelude period with post-ESRD mortality risk using Cox models adjusted for sociodemographics, cause of ESRD, Charlson comorbidity score, and comorbidities.

Results

Among 1219 veterans who underwent one or more total testosterone measurements in the two-year prelude period, those in the lowest testosterone tertile had higher mortality risk in expanded case-mix models (ref: highest tertile): adjusted HR (aHR) (95%CI) 1.31 (1.07-1.62) (Figure). A similar relationship between the lowest total testosterone tertile and higher death risk was observed when measurements were examined over six-month and one-year prelude periods: aHRs (95%CI): 1.70 (1.16-2.49) and 1.46 (1.11-1.93), respectively.

Conclusion

In male US veterans transitioning to dialysis, lower total testosterone levels in the pre-ESRD prelude period were associated with higher post-ESRD mortality risk. Further studies are needed to determine the specific underlying pathways between testosterone deficiency and mortality in this population, and whether administration of testosterone replacement therapy in the pre-ESRD prelude period can improve post-ESRD outcomes.

Funding

  • NIDDK Support