ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: SA-PO422

A Cohort Study to Assess the Role of Sensitivity C-Reactive Protein Level in the Evaluation of Activity and Prognosis of Microscopic Polyangiitis

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Author

  • Zhu, Bin, Hangzhou Hospital of Chinese Medicine, Hangzhou, ZheJiang, China
Background

To investigate the role of high-sensitive C-reactive protein(hs-CRP) level for the evaluation of activity and prognosis of microscopic polyangiitis(MPA).

Methods

A total of 149 patients with MPA were enrolled from June 23rd, 2008 to January 20th, 2017. We collected demographic characteristics, biochemical parameters and pathological changes. These patients were divided into high hs-CRP group and low hs-CRP group at the cutpoint of 7.05 of the median of hs-CRP of these patients to compare the clinical features and prognosis between these two groups. A Kaplan–Meier survival analysis was performed to compare the survival rate using a log-rank test.Cox proportional hazards models were used to evaluate the association between hs-CRP levels and outcomes.

Results

The patients with crescentic type in the high hs-CRP group was significantly higher than that in the low hs-CRP group. The patients with sclerotic type was lower than that in the low hs-CRP group. The cases to reach the primary outcome (death, renal replacement therapy) in the hs-CRP group were significantly higher than that in the low hs-CRP group(Figure 1). A high level of hs-CRP(HR: 3.11, 95% CI: 1.10 to 8.80) and renal interstitial infiltrates(HR: 2.94, 95% CI: 1.14 to 7.58) were independent risk factors for the progression of microscopic polyangiitis by a multivariable COX regression analysis.

Conclusion

Baseline serum hs-CRP level was a risk factor for the progression of microscopic polyangiitis, indicating that serum hs-CRP could be adopted as a clinical parameter for the evaluation of microscopic polyangiitis.

Figure 1. The patients survival rate in the high hs-CRP group was worse than that in the low hs-CRP group.