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Kidney Week

Abstract: TH-PO1006

108 Cases of Idiopathic Membranous Nephropathy Patients with Clinical and Pathological Analysis

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Author

  • Li, Xin, Tongji Hospital, Shanghai, China
Background

Idiopathic membranous nephropathy is the most common cause of adult nephrotic syndrome. Its onset is hidden and its progress is slow. The prognosis is different.Analyze the clinical and pathological characteristics of the patients with IMN will help us to get a better understanding of the disease process.The objective was to retrospectively analyze the clinical and pathological features of idiopathic membranous nephropathy in our single center.

Methods

The clinicopathological data of 108 patients with biopsy-proven IMN from January 2013 to December 2017 were analyzed retrospectively.IMN patients were divided into NS and non-NS groups.Analyse the clinical and pathological characteristics of these two groups.

Results

The average age was 57 years and 59.3% were male patients. Compared with patients without NS,IMN patients with NS were older,lower eGFR, higher total cholesterol,low density cholesterol and serum creatinine (P<0.05). The effective rate of conservative treatment in IMN patients without NS was 61.7%.The effective rate of immunosuppressive therapy in IMN patients with NS was 70.8%, and low serum albumin was an independent risk factor for the poor efficacy(p=0.021 OR 1.329).The effective rate of conservative treatment in IMN patients with NS was 47.3%,and low serum albumin was an independent risk factor for the poor efficacy(p=0.042 OR 1.201).

Conclusion

The remission rate of conservative treatment non-NS patients was not low. Hypoproteinemia may be a predictor of poor efficacy with NS patients.

Funding

  • Government Support - Non-U.S.