Abstract: INFO18
"GIGA-kids" -- Genomics of IgA-related diseases in kids
Session Information
- Informational Posters
October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category:
- No subcategory defined
Authors
- Kiryluk, Krzysztof, Columbia University, New York, New York, United States
- Balderes, Olivia, Columbia University, New York, New York, United States
- Bowers, Corinna, Midwest Pediatric Nephrology Consortium, Columbus, Ohio, United States
- Akchurin, Oleh M., Weill Cornell College of Medicine, New York, New York, United States
- Al-Akash, Samhar I., Driscoll Children's Hospital, Corpus Christi, Texas, United States
- Bou Matar, Raed, Cleveland Clinic, Cleveland, Ohio, United States
- Chishti, Aftab S., University of Kentucky, Lexington, Kentucky, United States
- Davis, T. Keefe, St. Louis Children's Hospital , St. Louis, Missouri, United States
- Flynn, Joseph T., Seattle Children's Hospital, Seattle, Washington, United States
- Hidalgo, Guillermo, Eastern Carolina University, Greenville, North Carolina, United States
- Lin, Fangming, Columbia University, New York, New York, United States
- Ranch, Daniel, UT Health San Antonio, San Antonio, Texas, United States
- Rheault, Michelle N., University of Minnesota, Minneapolis, Minnesota, United States
- Samsonov, Dmitry V., New York Medical College-Munger Pavilion, Valhalla, New York, United States
- Selewski, David T., University of Michigan , Ann Arbor, Michigan, United States
- Mason, Sherene, Connecticut Children's Medical Center, New Haven, Connecticut, United States
- D'Alessandri-Silva, Cynthia J., Connecticut Children's Medical Center, New Haven, Connecticut, United States
- Vasylyeva, Tetyana L., Texas Tech U. , Amarillo, Texas, United States
- Wenderfer, Scott E., Baylor College of Medicine, Houston, Texas, United States
- Weng, Patricia L., UCLA, Los Angeles, California, United States
- Smoyer, William E., Nationwide Children's Hospital, Columbus, Ohio, United States
- Nelson, Raoul D., Primary Children's Hospital, Salt Lake City, Utah, United States
- Wyatt, Robert J., University of Tennessee Memphis, Memphis, Tennessee, United States
- Gharavi, Ali G., Columbia University, New York, New York, United States
Description
IgA nephropathy (IgAN) represents the leading cause of kidney failure among young adults and is the most prevalent form of primary glomerulonephritis worldwide. Prior genetic studies in adults have discovered 20 distinct GWAS susceptibility loci and defined IgAN as an autoimmune trait with a complex genetic architecture. There is also a strong inverse relationship between the burden of GWAS risk alleles and the age of IgAN onset. These observations suggest that pediatric patients are likely enriched for genetic causes of disease, yet pediatric cohorts are not presently available for genetic studies.
The GIGA-Kids Study (Genomics of IgA-related disorders in kids, www.gigakids.org) is a multicenter collaborative study that aims to recruit over 1,000 North American children with IgAN or Henoch-Schönlein purpura (with or without nephritis). There are 27 sites nationwide actively recruiting patients. This study represents one of the largest recruitment efforts in the field of rare pediatric kidney disease. The study is in its third year of activity and has recruited over 405 patients in the U.S. alone. As of June 2017, the North American GIGA-kids cohort is the largest pediatric IgAN and HSP/N cohort to date.
Any patients diagnosed before the age of 21 (but without active HBV, HCV, HIV, autoimmune or liver disease), are eligible to participate. All study participants undergo genome–wide SNP genotyping, whole exome sequencing, and blood RNA-sequencing. The GIGA-Europe Network, which mirrors the North American study, aims to recruit additional 1,000 European patients across major nephrology centers in Italy, France, Poland, Sweden, the Netherlands, Croatia, Czech Republic, Hungary, Turkey, and the UK. Both the GIGA-kids and GIGA-Europe networks remain open to new collaborating centers. The GIGA network is sponsored by the IgA Nephropathy Foundation of America and the Midwest Pediatric Nephrology Consortium (MWPNC).
Funding
- IgA Nephropathy Foundation of America (Non-profit NGO).