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Abstract: INFO07

GUDMAP: GenitoUrinary Development Molecular Anatomy Project

Session Information

  • Informational Posters
    October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category:

  • No subcategory defined

Author

  • Valerius, M. Todd, Brigham and Women's Hospital, Boston, Massachusetts, United States

Group or Team Name

  • The GUDMAP Consortium
Description

The GenitoUrinary Development Molecular Anatomy Project (GUDMAP) is an open access online resource developed by a consortium of laboratories working to provide the scientific and medical community with gene and protein expression data, transgenic mice, high-resolution 2D and 3D morphological data, and tools to facilitate research and teaching in genitourinary (GU) development. The goal is to stimulate further research into genitourinary development by identifying novel cell types and gene expression domains in the kidneys, ureters, bladder, prostate, urethra, external genitalia, and associated reproductive structures. The GUDMAP database includes data from large-scale in situ hybridization screens, 3D Optical Projection Tomography (OPT) images, immunofluorescence, microarray, RNA-seq and scRNA-seq gene expression data, and high-resolution histology of the developing mouse and human GU system. Beyond tissue structures, GUDMAP includes characterization of nociceptors and associated cell types in pain processing of the murine urinary tract and pelvic region. Expression data and histological samples are annotated using a high-resolution ontology specific to the developing murine GU system and being adapted to the human GU system. The database is searchable by gene name, function, or anatomical structure, leading users to available annotated datasets including scRNA-seq data. GUDMAP initially focused on the murine GU system, but now has expanded to include gene expression and morphological data on the human GU and reproductive tract development. GUDMAP data are curated and freely accessible at www.gudmap.org.

Funding

  • GUDMAP is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).