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Abstract: TH-PO478

Normal Body Mass Index with Non-Alcoholic Fatty Liver Disease Is Associated with Coronary Calcification in Patients with CKD

Session Information

Category: Hypertension and CVD

  • 1401 Hypertension and CVD: Epidemiology, Risk Factors, and Prevention

Authors

  • Choi, Hoon Young, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Kim, Seok-hyung, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Kim, Tae hoon, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Kim, Hyunwook, Yonsei University College of Medicine Gangnam Severance Hospital, Seoul, GYEONGGI-DO, Korea (the Republic of)
  • Park, Hyeong cheon, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
Background

Increased coronary artery calcification (CAC) for assessing the burden of coronary atherosclerosis has been reported in patients with chronic kidney disease (CKD). Although non-alcoholic fatty liver disease (NAFLD) is associated with obesity and metabolic syndrome, it may also present in lean individuals. This study aimed to investigate whether normal body mass index (BMI) with NAFLD is associated with coronary artery calcification (CAC) in the patients with CKD.

Methods

Data from a total of 1,479 patients with CKD with normal BMI were provided from 2005 through 2017. CAC score was measured with computed tomography. BMI was considered to be normal if it was less than 25 kg/m2. To assess the central obesity, waist-to-hip ratio (WHR) was also obtained. NAFLD was diagnosed in patients with evidence of liver steatosis at ultrasonography.

Results

Six hundred ninety-nine (47.2%) patients had CAC in CKD with NAFLD. The CAC was significantly higher in the CKD patients with NAFLD than the CKD patients without NAFLD (66.2±238.9 vs. 39.8±158.2, p<0.001). After adjusting for age, gender, hypertension, diabetes, dyslipidemia, WHR, estimated glomerular filtration rate, fasting plasma glucose, total cholesterol, NAFLD was significantly associated with increased risk of CAC in CKD patients with normal BMI (OR=1.754, P<0.001).

Conclusion

Our study showed that NAFLD was significantly associated with CAC in the non-obese patients with CKD with normal BMI