ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005


The Latest on Twitter

Kidney Week

Abstract: TH-PO396

Serum Galactomannan and (1→3)-β-D-Glucan Testing for Rapid Detection of Fungal Peritonitis

Session Information

Category: Dialysis

  • 703 Dialysis: Peritoneal Dialysis


  • Kanjanabuch, Talerngsak, Medicine, Pathumwan, Thailand
  • Chamroensakchai, Tamonwan, chulalongkorn hospital, Bangkok, Thailand
  • Saejew, Thunvarat, chulalongkorn hospital, Bangkok, Thailand

Fungal peritonitis is one of the most serious complications of peritoneal dialysis. Early detection of the causative organism is a key determining outcome; however, routine culture is time consuming and KOH staining has very low sensitivity. Hence serum (1→3)-β-D-glucan (BG) or galactomannan (GM), both fungal cell wall components, may be candidate biomarkers of fungal peritonitis.


A comparative multi-centered cross-sectional analysis of paired serum and peritoneal dialysis fluid (PDF) BG (Fungitell, Cape Cod, MA, USA) and GM (Platelia Aspergillus Ag kits, Bio-rad, France) from all PD patients with and without fungal peritonitis (23 cases, 8 cases with bacteria and 23 cases control identified by culture), over a 1 year period, was performed.


PDF and serum of the fungal peritonitis group showed very high GM (2.42±2.15, 1.85±1.22) and BG (410.0±158.3, 355.9±246.9) compared to bacterial peritonitis (0.28±0.12, 0.34±0.14), (7.81±0, 7.81 ±0) and healthy control (0.42±0.16, 0.39±0.10), (7.81 ± 0, 7.81±0), respectively. A GM cut-off value at at 0.5 and BG at 80 pg/ml. showed positive predictive value (PPV) of GM test was 95.45% and negative predictive value (NPV) was 93.75%. The sensitivity and specificity of GM testing in PDF and serum were 91.3% and 96.8% respectively.


BG and GM in peritoneal dialysis fluid and serum with provisional cut-off values were applicable as surrogate biomarkers for the diagnosis of fungal peritonitis in PD patients.