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Abstract: PO1275

Patient-Reported Factors and Peritonitis Risk: Results from the Optimizing Prevention of Peritoneal Dialysis-Associated Peritonitis in the US Study (OPPUS)

Session Information

Category: Dialysis

  • 703 Dialysis: Peritoneal Dialysis

Authors

  • McCullough, Keith, Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States
  • Perl, Jeffrey, St. Michael’s Hospital, Toronto, Ontario, Canada
  • Al sahlawi, Muthana, St. Michael’s Hospital, Toronto, Ontario, Canada
  • Boudville, Neil, University of Western Australia, Perth, New South Wales, Australia
  • Ito, Yasuhiko, Aichi Medical University, Nagakute, Aichi, Japan
  • Kanjanabuch, Talerngsak, Chulalongkorn University, Bangkok, Thailand
  • Piraino, Beth M., University of Pittsburgh, Pittsburgh, Pennsylvania, United States
  • Schaubel, Douglas Earl, University of Pennsylvania, Philadelphia, Pennsylvania, United States
  • Schreiber, Martin J., DaVita Inc, Denver, Colorado, United States
  • Teitelbaum, Isaac, University of Colorado, Denver, Colorado, United States
  • Woodrow, Graham, St. James's University, Leeds, United Kingdom
  • Zhao, Junhui, Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States
  • Pisoni, Ronald L., Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States
Background

Peritoneal dialysis (PD)-associated peritonitis has been found to be associated with depression in a single-center study (Troidle 2003). Using international multicenter PDOPPS data, we investigated the association of peritonitis with reported symptoms of depression via the Center for Epidemiologic Studies Depression Scale (CES-D) and quality of life (QoL) measures.

Methods

We used Peritoneal Dialysis Outcomes and Practice Patterns Study phase 1 (2014-2018) data from Australia and New Zealand (A/NZ), Canada (CA), Japan (JP), Thailand (TH), the UK and US in cause-specific recurring-event survival models on peritonitis outcomes, stratified by previous episodes. Patient QoL) was estimated using the SF-12 Physical and Mental Health Composite Scores (PCS, MCS), and CES-D. Analyses were adjusted for age, years on PD, serum albumin level, residual urine, black race, sex, heart disease, diabetes, GI bleed, country, and prior peritonitis events.

Results

Peritonitis risk was associated with higher CES-D scores (p=.05). Patients who reported CES-D scores ≧ 15 had 27% higher peritonitis risk compared to patients who reported scores < 10. While associations were weaker for MCS (p=.69) and PCS (p=.40), scores that indicated the lowest tertile of QoL in these areas were associated with 6-7% higher peritonitis risk than scores in the highest tertile (table).

Conclusion

While the association between poorer QoL and peritonitis risk was weak and non-significant, the association between having greater symptoms of depression (per CES-D) and future peritonitis risk warrants further investigation, as depression may be a modifiable risk factor.

Hazard ratio of peritonitis, adjusted for case mix. Higher CES-D=more symptoms of depression, higher PCS, MCS = better QoL.

Funding

  • Other NIH Support