Kidney Week

Abstract: SU-OR22

Rate of Decline in Residual Kidney Function Before and After Peritoneal Dialysis Initiation: A Post Hoc Analysis of the IDEAL Study

Session Information

• Peritoneal Dialysis and Vascular Access: Research Abstracts
  October 25, 2020 | Location: Simulive
  Abstract Time: 05:00 PM - 07:00 PM

Category: Dialysis

• 703 Dialysis: Peritoneal Dialysis

Authors

• Ethier, Isabelle, Centre Hospitalier de L'Universite de Montreal, Montreal, Quebec, Canada

Isabelle Ethier, MD



Dr Isabelle Ethier has completed her medical training (2013) and residency program in Adult Nephrology (2018) at Université de Montréal, in Canada. She is currently appointed as a Nephrology Fellow at the Princess Alexandra Hospital, in Brisbane, Australia, where she is pursuing research and clinical work in home dialysis. She is also enrolled in a Master's degree in Biomedical Sciences -- Applied Clinical Research at Université de Montréal.

• Cho, Yeoung Jee, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

Yeoung Jee Cho,

• Hawley, Carmel, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

Carmel Hawley,

• Pascoe, Elaine, The University of Queensland Faculty of Medicine, Herston, Queensland, Australia

Elaine Pascoe,

• Viecelli, Andrea K., Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

Andrea K. Viecelli,

• Campbell, Scott B., Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

Scott B. Campbell,

• Van Eps, Carolyn L., Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

Carolyn L. Van Eps,

• Isbel, Nicole, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

Nicole Isbel,

• Cooper, Bruce A., Royal North Shore Hospital, St Leonards, New South Wales, Australia

Bruce A. Cooper,

• Harris, David, Westmead Institute for Medical Research, Westmead, New South Wales, Australia

David Harris,

• Pollock, Carol A., Royal North Shore Hospital, St Leonards, New South Wales, Australia

Carol A. Pollock,

• Wong, Muh Geot, Royal North Shore Hospital, St Leonards, New South Wales, Australia

Muh Geot Wong,

• Johnson, David W., Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

David W. Johnson,

Background

Residual kidney function (RKF) is associated with improved survival and quality of life in dialysis patients. Previous studies have suggested that commencement of peritoneal dialysis (PD) may slow RKF decline compared to the pre-dialysis period. We sought to evaluate the association between PD initiation and RKF decline in the Initiating Dialysis Early And Late (IDEAL) trial.

Methods

In this post hoc analysis of the IDEAL randomized controlled trial, PD participants were included if results from 24-hour urine collections had been recorded within 30 days of dialysis initiation (-30 to +30 days from start), and at least one value pre- and one value post-dialysis commencement were available. The primary outcome was slope of RKF decline, calculated as mean of urinary creatinine and urea clearances. Secondary outcomes included slope of urine volume decline and time from PD initiation to anuria.

Results

The study included 151 participants (79 early-start group, 72 late-start group). The slope of RKF decline was slower after PD commencement (-2.69±0.18 mL/min/1.73m²/yr) compared to before PD commencement (-4.09±0.33 mL/min/1.73m²/yr; change in slope +1.19 mL/min/1.73m²/yr, 95% CI 0.48-1.90, p<0.001). In contrast, urine volume decline was faster after PD commencement (-0.74±0.05 L/yr) compared to beforehand (-0.57±0.06 L/yr; change in slope -0.18 L/yr, 95%CI -0.34—-0.01, p=0.04). No differences were observed between the early- and late-start groups with respect to RKF decline, urine volume decline or time to anuria.

Conclusion

Commencement of PD was associated with a slower decline of RKF compared to the pre-dialysis period.

Figure 1. Trend of glomerular filtration rate (normalized to BSA) over time. Gray lines: individual patient measurements; black lines: predicted slopes in the pre- and post-dialysis initiation periods.

Funding

• Government Support - Non-U.S.