Abstract: PO2081
Urinary Magnesium Predicts Risk of Cardiovascular Disease in Pre-Dialysis CKD Patients
Session Information
- Hypertension and CVD: Epidemiology, Risk Factors, and Prevention
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1401 Hypertension and CVD: Epidemiology, Risk Factors, and Prevention
Authors
- Yuan, Qiongjing, Xiangya Hospital Central South University, Changsha, Hunan, China
- Xu, Hui, Xiangya Hospital Central South University, Changsha, Hunan, China
- Wang, Jinwei, Peking University First Hospital, Beijing, Beijing, China
Group or Team Name
- on behalf of the C-STRIDE study group
Background
24h Urinary magnesium concentration (24h UMg), an indicator of intestinal magnesium absorption, may provide a better insight in the connection of CKD progression.
Methods
We examined 3179 participants aged 18 to 74 years pre-dialysis patients in the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) study. We performed a time-to-event analysis of the data using Kaplan-Meier Survival model, Cox proportional hazard and competing risks Fine and Gray sub-distribution hazard models.
Results
During the median follow-up of 4.19 (IQR 3.432-5.09) years, lower incidence rate of ESRD events was observed with increases in 24h UMg (Figure 1). Higher incidence rate of CVD events was seen with increase in 24 h UMg (Figure 2). After adjustment for demographic and traditional ESRD risk factors, 24h UMg was strongly associated with risk of CVD (HR of 1.509 [95% CI 1.031-2.208])(Table 1).
Conclusion
24h UMg risk variants display a modest association with CVD in pre-dialysis CKD patients.
Table 1 Association of 24h UMg with CVD events among pre-dialysis CKD patients
| UMg ratio | Model 1 | Model 2 |
| HR (95% CI) | HR (95% CI) | |
| Total CKD patients (n= 3179) | ||
| <3.05 | 1.00 (Ref) | 1.00 (Ref) |
| ≥3.05 | 1.466(1.027, 2.093) | 1.509(1.031,2.208) |
| p for trend | 0.035** | 0.034** |
** Statistically significant at 0.05. Model1 Age, gender Model2 Age, gender, CVD, HBP, DM, drinking, smoking, UA, HCO3-, TC, LDL, eGFR, BMI, ACR, iPTH, HGB, sP, sMg, sCa, sK, sNa, UNa, UK
Figure 1. Kaplan-Meier curve for ESRD events according to binary of 24h UMg
Figure 2. Kaplan-Meier curve for CVD events according to binary of 24h UMg
Funding
- Government Support - Non-U.S.