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Abstract: PO2081

Urinary Magnesium Predicts Risk of Cardiovascular Disease in Pre-Dialysis CKD Patients

Session Information

Category: Hypertension and CVD

  • 1401 Hypertension and CVD: Epidemiology, Risk Factors, and Prevention

Authors

  • Yuan, Qiongjing, Xiangya Hospital Central South University, Changsha, Hunan, China
  • Xu, Hui, Xiangya Hospital Central South University, Changsha, Hunan, China
  • Wang, Jinwei, Peking University First Hospital, Beijing, Beijing, China

Group or Team Name

  • on behalf of the C-STRIDE study group
Background

24h Urinary magnesium concentration (24h UMg), an indicator of intestinal magnesium absorption, may provide a better insight in the connection of CKD progression.

Methods

We examined 3179 participants aged 18 to 74 years pre-dialysis patients in the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) study. We performed a time-to-event analysis of the data using Kaplan-Meier Survival model, Cox proportional hazard and competing risks Fine and Gray sub-distribution hazard models.

Results

During the median follow-up of 4.19 (IQR 3.432-5.09) years, lower incidence rate of ESRD events was observed with increases in 24h UMg (Figure 1). Higher incidence rate of CVD events was seen with increase in 24 h UMg (Figure 2). After adjustment for demographic and traditional ESRD risk factors, 24h UMg was strongly associated with risk of CVD (HR of 1.509 [95% CI 1.031-2.208])(Table 1).

Conclusion

24h UMg risk variants display a modest association with CVD in pre-dialysis CKD patients.

Table 1 Association of 24h UMg with CVD events among pre-dialysis CKD patients
UMg ratioModel 1Model 2
 HR (95% CI)HR (95% CI)
Total CKD patients (n= 3179)  
<3.051.00 (Ref)1.00 (Ref)
≥3.051.466(1.027, 2.093)1.509(1.031,2.208)
p for trend0.035**0.034**

** Statistically significant at 0.05. Model1 Age, gender Model2 Age, gender, CVD, HBP, DM, drinking, smoking, UA, HCO3-, TC, LDL, eGFR, BMI, ACR, iPTH, HGB, sP, sMg, sCa, sK, sNa, UNa, UK

Figure 1. Kaplan-Meier curve for ESRD events according to binary of 24h UMg

Figure 2. Kaplan-Meier curve for CVD events according to binary of 24h UMg

Funding

  • Government Support - Non-U.S.