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Kidney Week

Abstract: PO1881

Clinical Characteristics of Acute Glomerulonephritis with Presentation of Nephrotic Syndrome at Onset in Children

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Ge, Huipeng, Xiangya Hospital Central South University, Changsha, Hunan, China
  • Yuan, Qiongjing, Xiangya Hospital Central South University, Changsha, Hunan, China
  • Xiao, Xiangcheng, Xiangya Hospital Central South University, Changsha, Hunan, China
Background

Acute glomerulonephritis (AGN) is a common disease in children, which placed a huge burden on developing countries. Prognosis of it may not always good. However, the clinical characteristics of AGN with nephrotic syndrome (NS) at onset were not fully clarified.

Methods

113 cases were analyzed retrospectively. Clinical data, pathological results and prognosis between AGN with NS (AGN-NS) and AGN without NS (AGN-no-NS) were compared.

Results

20 (17.7%) of 113 patients were AGN-NS. The patients with AGN-NS were more likely to have hypertension (55.0% vs. 25.8%) and acute kidney injury (AKI) (50% vs. 17.2%). The AKI was significantly related to the manifestation of AGN-NS in children (OR=3.812, P=0.040). Compared with the AGN-no-NS, the immunosuppressive treatments were more common in AGN-NS. A severer pathological grade was significantly related to the lower C3 fraction, estimated glomerular filtration rate (eGFR) and AKI, but not the performance of AGN-NS. There was no difference in prognosis between two groups.

Conclusion

The AKI was significantly associated with AGN-NS. The prognosis of AGN-NS and AGN-no-NS in our study was almost good. Given the fact that AGN-NS patients more likely to use the immunosuppressive therapy, the long-term outcome of AGN-NS is worth a further research.