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Kidney Week

Abstract: PO2126

Weight Gain Is a Risk Factor for the Progression of Coronary Artery Calcification in CKD: From the KNOW-CKD Study

Session Information

Category: Hypertension and CVD

  • 1402 Hypertension and CVD: Clinical, Outcomes, and Trials

Authors

  • Kim, Ji Hye, Kangbuk Samsung Medical Center, Jongno-gu, Seoul, Korea (the Republic of)
  • Hyun, Young Youl, Kangbuk Samsung Medical Center, Jongno-gu, Seoul, Korea (the Republic of)
Background

In chronic kidney disease (CKD), patients with high body mass index or weight gain have better survival. However, their cardiovascular risk is uncertain. The aim of this study was to investigate the relationship between weight changes and the progression of coronary artery calcification (CAC) in CKD.

Methods

This study analyzed 839 participants (Mean age 52.51±12.03, Males 41.12%) from the KNOW-CKD cohort. Changes in weight between baseline and 4 year follow-up period were categorized in tertiles: first tertile (T1) (-31.3kg to -1.1kg), second tertile (T2) (-1kg to 0.9kg) and third tertile (T3) (1kg to 30kg). The coronary artery calcium score (CACS) was assessed using cardiac computed tomography at baseline and 4 years after enrolment. The CAC progression was defined as increase of CACS after 4 years.

Results

The study participants’ baseline median CACS was 0.0 (median) [0 (25th quartile)- 34.5(75th quartile)] and 387 (46.13%) participants had baseline CACS above 0. After 4 years, numbers of patients in each tertile was 247 (29.4%) in T1, 258 (30.8%) in T2 and 334 (39.8%) in T3. Median difference in CACS between baseline and follow-up was 2 [0 -69.3] in T1, 0 [0-47.2] in T2 and 6.4 [0-64.77] in T3. (p=0.088) Multivariate adjusted odds ratios (OR) [95% confidence interval] (95% CI) for CAC progression in T1 and T3 group compared to T2 group were 1.21 [0.79-1.85] and 1.80 [1.20-2.70].

Conclusion

Third tertile group, which gained between 1 to 30kg after 4 years, was significantly and independently associated with CAC progression compared to weight stable second tertile group in Korean predialysis CKD patients. These results suggest that preventing excessive weight gain might help prevent cardiovascular complications in CKD.