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Abstract: PO1178

Hand Grip and Leg Muscle Strength in Hemodialysis Patients and Its Determinants

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Author

  • Cha, Ran-hui, National Medical Center, Seoul, Seoul, Korea (the Republic of)
Background

Chronic kidney disease is associated with chronic inflammation and progressive loss of peripheral muscle strength and the ability to exercise, and these changes are more pronounced in patients on hemodialysis (HD). We evaluated the hand grip and leg muscle strength in patients receiving HD and tried to find factors associated with muscle strength.

Methods

We screened hand grip (opposite to fistula side) and leg muscle strength (both sides) at single center (n=112) by using digital hand and leg dynamometer (T.K.K.5401 and 5710e/5715, Takei scientific instruments Co. Ltd., Niigata, Japan).

Results

Mean age was 62.6 years, and 73.2% of patients were men. Diabetes was the cause of kidney failure in 50% of patients and median HD vintage was 34 months. 77.7% of patients answered ‘yes’ to regular home exercise and 33% of patients regularly participated in the hospital based latex-band exercise. Hand grip strength (HGS) and leg muscle strength (LMS) showed good correlation (r = 0.715, p < 0.001). HGS (25.1 vs. 17.0 kg) and LMS (30.1 vs. 20.4 kg) were better in men (p < 0.001 and p < 0.001, respectively). Older patients (≥ 60 years) showed decreased LMS than others in men and women (p = 0.01 and p = 0.04, respectively), but HGS was not different by age. Patients doing regular home or hospital based exercise showed higher HGS (24.2 vs. 18.6 kg, p = 0.01) but LMS did not show statistical significance (29.3 vs. 23.6 kg, p = 0.19). Serum albumin and creatinine showed positive correlation with HGS and LMS, and hs-CRP was negatively correlated only with HGS. Multiple linear regression analysis proved male sex, younger age, and any type of exercise were factors associated with better HGS and LMS.

Conclusion

Sex, age, and exercise were the most important determinants of muscle strength in HD patients. We need to encourage patients to do regular home or group exercise and introduce new feasible form of exercise for HD patients.