Abstract: PO1581
End-of-Study Results from ACQUIRE: A Study Measuring Quality of Life, Treatment Preference, and Treatment Satisfaction of Autosomal Dominant Polycystic Kidney Disease Patients in Europe
Session Information
- Cystic Kidney Diseases: Emerging Concepts, Biomarkers, and Clinical Trials
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Genetic Diseases of the Kidneys
- 1001 Genetic Diseases of the Kidneys: Cystic
Authors
- Joly, Dominique, Nephrology Department, Necker Hospital, Paris, France
- Doll, Helen, Clinical Outcomes Solutions Ltd, Folkestone, United Kingdom
- De Jong-Laird, Anne, Otsuka Pharmaceutical Europe Ltd, Wexham, Buckinghamshire, United Kingdom
- Kabra, Madhusudan, Otsuka Pharmaceutical Europe Ltd, Wexham, Buckinghamshire, United Kingdom
Background
Little is known about health-related quality of life (HRQoL) and patient (pt) reported outcome (PRO) measures in early autosomal dominant polycystic kidney disease (ADPKD), and longitudinal studies are lacking.
Methods
ACQUIRE (NCT02848521) was a prospective, non-interventional, real-world observational study in pts with early and rapidly progressing ADPKD (chronic kidney disease [CKD] stages 1–3) across 7 European countries. The primary objective was to measure changes in Physical Health Composite Scale (PCS) scores of the 12-item Short Form Health Survey (SF-12) over 18 months. Other objectives included changes in SF-12 Mental Health Composite Scale (MCS) scores, ADPKD-specific PROs including the ADPKD-Impact Scale (IS), -Urinary Impact Scale (UIS) and -Pain & Discomfort Scale (PDS), and treatment satisfaction questionnaire (TSQM-9).
Results
Patient demographics were previously reported. Overall 305/403 (75.7%) were included in the PRO analysis set. Changes from baseline in SF-12 (PCS and MCS), ADPKD-IS (Physical and Emotional domains) and TSQM-9 (Global Satisfaction) through Month 18 are presented in Figure 1. CKD-1 pts and pts not receiving tolvaptan reported the lowest treatment satisfaction. No consistent changes were observed for ADPKD-UIS and ADPKD-PDS (not shown).
Conclusion
Over an 18-month timeframe, pts reported reduced scores in the PCS component of SF-12, deterioration in the physical components of ADPKD-IS and reduced treatment satisfaction. These data suggest that continued disease progression negatively impacts the HRQoL of pts with early stages of ADPKD and implies there may be current unmet treatment needs in this pt population.
Figure 1. Change from Baseline in PROs
Funding
- Commercial Support –