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Kidney Week

Abstract: PO0272

Reported Caregiver Burden in CKD with and Without Anemia: A US-Based Survey

Session Information

Category: Anemia and Iron Metabolism

  • 200 Anemia and Iron Metabolism

Authors

  • Michalopoulos, Efstathios N., Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, New Jersey, United States
  • Gauthier-Loiselle, Marjolaine, Analysis Group, Inc., Montreal, Quebec, Canada
  • Sanon, Myrlene, Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, New Jersey, United States
  • Serra, Elizabeth, Analysis Group, Inc., Montreal, Quebec, Canada
  • Bungay, Rebecca, Analysis Group, Inc., Montreal, Quebec, Canada
  • Clynes, Diana, American Association of Kidney Patients, Tampa, Florida, United States
  • Cloutier, Martin, Analysis Group, Inc., Montreal, Quebec, Canada
  • Kahle, Erin, American Association of Kidney Patients, Tampa, Florida, United States
  • Guerin, Annie, Analysis Group, Inc., Montreal, Quebec, Canada
  • Farag, Youssef MK, Akebia Therapeutics, Inc., Cambridge, Massachusetts, United States
  • Wish, Jay B., Division of Nephrology, Indiana University, Indianapolis, Indiana, United States
Background

Chronic kidney disease (CKD) has a far-reaching impact that extends beyond the affected patients. An online survey was conducted to explore caregiver burden in providing care for an adult with CKD, with or without anemia.

Methods

The survey was administered in January-February 2020 to adult participants recruited from the American Association of Kidney Patients (AAKP) and a third-party recruiter, Dynata. Eligible participants provided care to an adult with CKD within the last 4 weeks. The 15-20 minute survey included questions related to caregiver and patient demographics, clinical characteristics, preferences on anemia treatment, caregiver quality of life (Burden Scale for Family Caregivers [BSFC-S]), and work productivity (Work Productivity Activity Impairment: Caregiver). Outcomes were summarized descriptively for caregivers of patients with anemia (A+) and without anemia (A-).

Results

Among 258 caregivers who completed the survey, 42.6% cared for a patient with anemia (A+; non-dialysis dependent [NDD], 38.2%; dialysis dependent [DD], 61.8%) and 57.4% cared for a patient without anemia (A-; NDD, 45.9%; DD, 54.1%). Nearly 90% identified themselves as the primary caregiver; ≥60% were aged 35 to 64 years and >70% were female. Comorbidities reported most frequently by caregivers included anxiety (A+, 43.6%; A-, 32.4%), depression (A+, 36.4%; A-, 30.4%), headache (A+, 35.5%; A-, 31.8%), and sleep disturbance (A+, 30.9%; A-, 31.1%). Most caregivers reported a high burden (BSFC-S≥15: A+, 69.1%; A-, 58.8%) and work impairment (absenteeism: A+, 19.0%; A-, 14.8%; presenteeism: A+, 37.9%; A-, 33.2%). In the A+ group, >75% of caregivers described anemia as being moderate or severe, and >90% of patients had received anemia treatment in the past month (oral iron, 45.5%; intravenous iron, 33.6%; erythropoiesis-stimulating agents, 22.7%; red blood cell transfusion, 20.9%). If a patient was to initiate a new anemia treatment, 46.4% of caregivers would prefer an oral agent, of which 41.2% prefer a once daily formulation.

Conclusion

There is substantial burden experienced by caregivers of patients with CKD, especially when anemia is present. Further studies are needed to better understand its full extent and explore support strategies for caregivers.

Funding

  • Commercial Support