ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: PO2405

Potential Combined Use of Kidney Donor Profile Index (KDPI) and Estimated Post-Transplant Survival (EPTS) Scales to Predict eGFR Decline in Deceased Donor Kidneys

Session Information

Category: Transplantation

  • 1902 Transplantation: Clinical

Authors

  • Maggiani, Pablo, Renal Transplant Unit, National Medical Center ”20 de Noviembre”, Mexico City, Mexico
  • Hernández-Estrada, Sergio, Renal Transplant Unit, National Medical Center ”20 de Noviembre”, Mexico City, Mexico
  • Diaz Avendaño, Odette Del Carmen, Renal Transplant Unit, National Medical Center ”20 de Noviembre”, Mexico City, Mexico
  • Flores, Christian Perez, Renal Transplant Unit, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico
  • Gomez-Navarro, Benjamin, Centro Medico Nacional de Occidente, Guadalajara, Mexico
  • Ramirez, Maria Guadalupe Ramirez, Renal Transplant Unit, National Medical Center ”20 de Noviembre”, Mexico City, Mexico
  • Cano, Jose Horacio, Renal Transplant Unit, National Medical Center ”20 de Noviembre”, Mexico City, Mexico
  • Oseguera-Vizcaino, Maria Concepcion, Renal Transplant Unit, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico
  • Ovando-Morga, Daniel Fernando, Renal Transplant Unit, National Medical Center ”20 de Noviembre”, Mexico City, Mexico
  • Matias Carmona, Mayra May, Renal Transplant Unit, National Medical Center ”20 de Noviembre”, Mexico City, Mexico
Background

Utility of the sum of EPTS and KDPI scales to predict the decline of eGFR in patients who received a cadaveric donor transplant. Assess the reproducibility of the Organ Assignment System of the USA in our country.

Methods

128 deceased-donor kidney transplant recipients at two National Mexican Hospitals between 2015 – 2017, retrospective, observational cohort study over 36 months following transplant.

We include age, gender, primary renal disease, sensitization events, peak panel-reactive antibody, cold ischemia time, dialysis type and vintage, KDPI and EPTS, DGF, PTDM, Acute rejection, eGFR and cause of graft failure

P. outcome: Relationship between a decrease >30% eGFR and the different combined scores of the KDPI and EPTS scales.

Results

The sum of the scores of the EPTS and KDPI scales >81% had a sens. 76% and a spec. 84% to predict a >30% decline in eGFR. AUC 80.8% (95% [CI] 0.002 to 0.005, p < 0.001).
Multivariable Cox proportional hazard model: the sum of EPTS and KDPI scores >81% was associated with a 9.9-fold increase in losing more than 30% eGFR over the 36-months follow-up ( [adjHR] 9.9; 95% [CI] 1.85 to 53.6, p = 0.007).
Acute rejection was associated with a 3.1-fold increase in losing more than 30% eGFR ( [adjHR] 3.1; 95% [CI] 1.15 to 8.72, p = 0.02).

Conclusion

Observing the donor and the recipient as a sum can be an new tool that helps us to predict the decline eGFR in Deceased Donor Kidneys transplants