Kidney Week

Abstract: PO2405

Potential Combined Use of Kidney Donor Profile Index (KDPI) and Estimated Post-Transplant Survival (EPTS) Scales to Predict eGFR Decline in Deceased Donor Kidneys

Session Information

• Clinical and Immunologic Predictors of Post-Transplant Outcomes
  October 22, 2020 | Location: On-Demand
  Abstract Time: 10:00 AM - 12:00 PM

Category: Transplantation

• 1902 Transplantation: Clinical

Authors

• Maggiani, Pablo, Renal Transplant Unit, National Medical Center ”20 de Noviembre”, Mexico City, Mexico

Pablo Maggiani,

• Hernández-Estrada, Sergio, Renal Transplant Unit, National Medical Center ”20 de Noviembre”, Mexico City, Mexico

Sergio Hernández-Estrada,

• Diaz Avendaño, Odette Del Carmen, Renal Transplant Unit, National Medical Center ”20 de Noviembre”, Mexico City, Mexico

Odette Del Carmen Diaz Avendaño,

• Flores, Christian Perez, Renal Transplant Unit, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico

Christian Perez Flores,

• Gomez-Navarro, Benjamin, Centro Medico Nacional de Occidente, Guadalajara, Mexico

Benjamin Gomez-Navarro,

• Ramirez, Maria Guadalupe Ramirez, Renal Transplant Unit, National Medical Center ”20 de Noviembre”, Mexico City, Mexico

Maria Guadalupe Ramirez Ramirez,

• Cano, Jose Horacio, Renal Transplant Unit, National Medical Center ”20 de Noviembre”, Mexico City, Mexico

Jose Horacio Cano,

• Oseguera-Vizcaino, Maria Concepcion, Renal Transplant Unit, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico

Maria Concepcion Oseguera-Vizcaino,

• Ovando-Morga, Daniel Fernando, Renal Transplant Unit, National Medical Center ”20 de Noviembre”, Mexico City, Mexico

Daniel Fernando Ovando-Morga,

• Matias Carmona, Mayra May, Renal Transplant Unit, National Medical Center ”20 de Noviembre”, Mexico City, Mexico

Mayra May Matias Carmona,

Background

Utility of the sum of EPTS and KDPI scales to predict the decline of eGFR in patients who received a cadaveric donor transplant. Assess the reproducibility of the Organ Assignment System of the USA in our country.

Methods

128 deceased-donor kidney transplant recipients at two National Mexican Hospitals between 2015 – 2017, retrospective, observational cohort study over 36 months following transplant.

We include age, gender, primary renal disease, sensitization events, peak panel-reactive antibody, cold ischemia time, dialysis type and vintage, KDPI and EPTS, DGF, PTDM, Acute rejection, eGFR and cause of graft failure

P. outcome: Relationship between a decrease >30% eGFR and the different combined scores of the KDPI and EPTS scales.

Results

The sum of the scores of the EPTS and KDPI scales >81% had a sens. 76% and a spec. 84% to predict a >30% decline in eGFR. AUC 80.8% (95% [CI] 0.002 to 0.005, p < 0.001).
Multivariable Cox proportional hazard model: the sum of EPTS and KDPI scores >81% was associated with a 9.9-fold increase in losing more than 30% eGFR over the 36-months follow-up ( [adjHR] 9.9; 95% [CI] 1.85 to 53.6, p = 0.007).
Acute rejection was associated with a 3.1-fold increase in losing more than 30% eGFR ( [adjHR] 3.1; 95% [CI] 1.15 to 8.72, p = 0.02).

Conclusion

Observing the donor and the recipient as a sum can be an new tool that helps us to predict the decline eGFR in Deceased Donor Kidneys transplants