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Abstract: PO2043

Prevalence and Risk Factors of High-Altitude Hyperuricemia in the Bai Ethnic Group

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1300 Health Maintenance, Nutrition, and Metabolism

Authors

  • Gao, Chenni, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital Department of Nephrology, Shanghai, Shanghai, China
  • Chen, Xiaonong, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital Department of Nephrology, Shanghai, Shanghai, China
Background

The Bai ethnic group is one of the 55 minorities in the People's Republic of China. Hyperuricemia is not rare among this ethnic partly due to the chronic exposure to high altitude. However, the prevalence of hyperuricemia in the Bai ethnic group remains unclear.

Methods

We collected retrospectively the demographic characteristics and laboratory measurements of 1393 Bai ethnic adults undergoing annual medical examination during Jan 2019 to Dec 2019 in the People's Hospital of Jianchuan County (average altitude 2300m), Yunnan Province. We investigated the prevalence of hyperuricemia as well as its clinical features and risk factors.

Results

Of the 1393 participants enrolled in the study, the prevalence of hyperuricemia was 24.8%, and the prevalence was significantly higher in male gender (33.2% in men vs. 11.0% in women, P<0.001). The prevalence of hyperuricemia increased from 19.2% among participants aged 30-40 years to 30.1% among participants aged 50 years and older. Also, the prevalence elevated from 17.2% among participants with normal body mass index (BMI) to 35.5% among those who were overweighed/obese. Interestingly, we found a positive correlation between hemoglobin level (Hb) and serum uric acid (β=2.19, P<0.01). Logistic regression analysis revealed main risk factors for hyperuricemia in the Bai ethnic group included age, sex, BMI, systolic blood pressure (SBP) and Hb.

Conclusion

Hyperuricemia is common in the Bai ethnic group. Besides traditional risk factors such as age, sex and BMI, polycythemia secondary to chronic exposure to high altitude may also contribute to the hyperuricemia.

Fig 1 Prevalence of hyperuricemia and serum uric acid level in different age group (Left: Prevalence of hyperuricemia, Right: serum uric acid level). *P<0.001

Fig 2 Prevalence of hyperuricemia and serum uric acid level in different BMI group (Left: Prevalence of hyperuricemia, Right: serum uric acid level). *P<0.001