Kidney Week

Abstract: PO0533

Modification of the Association Between Dipstick Hematuria and Decline in Kidney Function by Proteinuria: Results from a Longitudinal Nationwide Survey

Session Information

• CKD Health Services Research
  October 22, 2020 | Location: On-Demand
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Tasaki, Hikari, Nara Medical University, Kashiwara, Nara, Japan

Hikari Tasaki,

• Eriguchi, Masahiro, Nara Medical University, Kashiwara, Nara, Japan

Masahiro Eriguchi,

• Yoshida, Hisako, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan

Hisako Yoshida,

• Nishimoto, Masatoshi, Nara Medical University, Kashiwara, Nara, Japan

Masatoshi Nishimoto,

• Kosugi, Takaaki, Nara Medical University, Kashiwara, Nara, Japan

Takaaki Kosugi,

• Kasahara, Masato, Nara Medical University, Kashiwara, Nara, Japan

Masato Kasahara,

• Iseki, Kunitoshi, Nakamura clinic, Urazoe city, Japan

Kunitoshi Iseki,

• Asahi, Koichi, Iwate Medical University, Morioka, Iwate, Japan

Koichi Asahi,

• Yamagata, Kunihiro, University of Tsukuba, Tsukuba, Ibaraki, Japan

Kunihiro Yamagata,

• Konta, Tsuneo, Yamagata University Faculty of Medicine Graduate School, Yamagata, Yamagata, Japan

Tsuneo Konta,

• Fujimoto, Shouichi, Miyazaki University, Miyazaki, Miyazaki, Japan

Shouichi Fujimoto,

• Narita, Ichiei, Niigata University, Niigata, Niigata, Japan

Ichiei Narita,

• Shibagaki, Yugo, Saint Marianna University School of Medicine, Kawasaki, Kanagawa, Japan

Yugo Shibagaki,

• Moriyama, Toshiki, Osaka University Health Care Center, Suita, Osaka, Japan

Toshiki Moriyama,

• Kondo, Masahide, University of Tsukuba, Tsukuba, Ibaraki, Japan

Masahide Kondo,

• Watanabe, Tsuyoshi, Fukushima Medical University School of Medicine, Fukushima, Japan

Tsuyoshi Watanabe,

• Tsuruya, Kazuhiko, Nara Medical University, Kashiwara, Nara, Japan

Kazuhiko Tsuruya,

Background

We hypothesize that proteinuria has a modification effect on the association of hematuria with decline in kidney function.

Methods

Participants were recruited who have undergone multiple nationwide specific health checks between 2008 and 2014 and have been observed for ≥2 years. We divided the participants into two and three categories according to hematuria and proteinuria, respectively. Using analysis of covariance, changes in eGFR over time (delta-eGFR) adjusted for clinically relevant factors were examined among hematuria category stratified by proteinuria category.

Results

Among 253,679 participants, median delta-eGFR was -0.36 mL/min/1.73m² per year (IQR: -2.25-0.54) during a median observation period of 4.0 years (IQR: 3.1-5.0), with a median age of 65 years (IQR: 60-68) and median baseline eGFR of 75 mL/min/1.73m² (IQR: 65-87). Compared to non-hematuria group, hematuria group had a greater eGFR decline rate even after adjusting confounders including proteinuria category. When stratified by proteinuria category, hematuria-related eGFR decline rate gradually increased as the proteinuria category progressed (P for interaction <0.001).

Conclusion

Among general population, delta-eGFR levels with and without hematuria were comparable in the absence of proteinuria, but proteinuria levels had a synergistic effect on eGFR decline rate associated with hematuria.