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Abstract: PO2130

Water Intake and Blood Pressure in Children: Results from the SPA Project

Session Information

Category: Hypertension and CVD

  • 1403 Hypertension and CVD: Mechanisms

Authors

  • Ardissino, Gianluigi, Pediatric Nephrology, Dialysis and Transplantation, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy
  • Perrone, Michela, Pediatric Nephrology, Dialysis and Transplantation, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy
  • Ghiglia, Silvia A.C, Cardiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
  • Salice, Patrizia, Cardiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
  • Tel, Francesca, Pediatric Department, Vittore Buzzi Children's Hospital, University of Milano, Milano, Italy
  • Capone, Valentina, Pediatric Nephrology, Dialysis and Transplantation, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy
  • Mancuso, Maria Cristina, Pediatric Nephrology, Dialysis and Transplantation, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy
  • Piantanida, Sandra, Polo Materno Infantile - Ospedale F. del Ponte, Varese, Italy
  • Di michele, Silvia, UOC Pediatria Ospedale di Pescara, Pescara, Italy

Group or Team Name

  • SPA Project
Background

Sodium (Na) intake is involved in the development of hypertension (HPT); to reduce NaI is important in the treatment of HPT, but the increase in renal Na excretion might also be a potential preventive and/or therapeutic opportunity. The SPA Project studied blood pressure (BP) in relation to water (H2O) andNa intake with the working hypothesis that an increased water I can improve renal Na handling.

Methods

339 healthy, non-overweight children (166 girls), 5.7 years old (IQR: 5.3-6.2) were characterized for: BP (using standardized multiple office BP measurement), Na and water intake (by means of urinary Na and creatinine from 4 samples taken in 4 different days). After categorizing subjects as low/high Na and low/high water intake (based on median value), BP was compared.

Results

Among children with higher Na intake, those introducing more water, showed a significantly (p<0.001) lower BP (both systolic and diastolic) compared to those who drink less (figure). This difference was not observed among children with lower Na intake.

Conclusion

Our findings support the hypothesis that an increased water intake, reduces BP perhaps by increasing Na renal excretion. We speculate that this simple, highly acceptable, inexpensive and harmless measure might have a role in preventing and minimizing the epidemics of HPT and related morbidities.