Abstract: PO0080
Impact of AKI on In-Hospital Outcomes in Chinese Patients with Community-Acquired Pneumonia
Session Information
- AKI Clinical, Outcomes, and Trials - 1
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 102 AKI: Clinical, Outcomes, and Trials
Authors
- Chen, Dawei, Nanjing First Hospital, Nangjing, Jiangsu, China
- Wan, Xin, Nanjing First Hospital, Nangjing, Jiangsu, China
Background
Acute kidney injury (AKI) is common in community acquired pneumonia (CAP). However, the impact of AKI on in-hospital outcomes of patients with CAP in the population of Chinese remains largely unknown.
Methods
Multiple Cox regression models were employed to identify the association between AKI and in-hospital mortality and 30-day mortality.
Results
4213 patients were included, and 950 (22.5%) patients were AKI. The independent risk factors for AKI were age, male, hypertension, cardiac dysfunction, diabetes, chronic kidney disease, acute respiratory failure, diuretic, vasoactive drugs, and CURB-65. After multivariable Cox regression, independent risk factors of in-hospital mortality and 30-day mortality were similar: AKI, ACEI/ARB, hypertension, CURB-65, acute respiratory failure, and using vasoactive drugs. Patients developed AKI had increased 1.31-fold (HR 1.31, 95 % CI, 1.04–1.66, P = 0.023) and 1.29-fold (HR 1.29, 95 % CI, 1.02–1.62, P = 0.033) risk for in-patient mortality and 30-day mortality, respectively. In addition, patients with AKI were more vulnerable to require intensive care unit (ICU) admission (42.9% vs. 11.4%; P < 0.001), mechanical ventilation (33.8% vs. 9.3%; P < 0.001), invasive mechanical ventilation (25.9% vs. 5.8%; P < 0.001), non-invasive mechanical ventilation (25.4% vs. 7.1%; P < 0.001), and had a longer length of hospital stay (14 days vs. 10 days; P < 0.001) than those without AKI.
Conclusion
AKI was common in Chinese patients with CAP. Patients with CAP who developed AKI had worse in-hospital outcomes.