Kidney Week

Abstract: PO0464

Association Between CKD and New Onset of Dyslipidemia: Results from a Longitudinal Nationwide Survey

Session Information

• CKD Risk Factors: Diet, Environment, Lifestyle
  October 22, 2020 | Location: On-Demand
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Kosugi, Takaaki, Nara Medical University, Kashihara, Nara, Japan

Takaaki Kosugi,

• Eriguchi, Masahiro, Nara Medical University, Kashihara, Nara, Japan

Masahiro Eriguchi,

• Yoshida, Hisako, Osaka City University Graduate School of Medicine School of Medicine, Osaka, Osaka, Japan

Hisako Yoshida,

• Tasaki, Hikari, Nara Medical University, Kashihara, Nara, Japan

Hikari Tasaki,

• Nishimoto, Masatoshi, Nara Medical University, Kashihara, Nara, Japan

Masatoshi Nishimoto,

• Kasahara, Masato, Institute for Clinical and Translational Science Nara Medical University Hospital, Kashiara, Nara, Japan

Masato Kasahara,

• Iseki, Kunitoshi, Nakamura Clinic, Urazoe, Okinawa, Japan

Kunitoshi Iseki,

• Asahi, Koichi, Iwate Medical University, Morioka, Iwate, Japan

Koichi Asahi,

• Yamagata, Kunihiro, University of Tsukuba, Tsukuba, Ibaraki, Japan

Kunihiro Yamagata,

• Konta, Tsuneo, Yamagata University Graduate School of Medical Science, Yamagata, Yamagata, Japan

Tsuneo Konta,

• Fujimoto, Shouichi, University of Miyazaki, Miyazaki, Miyazaki, Japan

Shouichi Fujimoto,

• Narita, Ichiei, Niigata University, Niigata, Niigata, Japan

Ichiei Narita,

• Shibagaki, Yugo, St Marianna University Hospital, Kawasaki, Kanagawa, Japan

Yugo Shibagaki,

• Moriyama, Toshiki, Osaka University Health Care Center, Suita, Osaka, Japan

Toshiki Moriyama,

• Kondo, Masahide, University of Tsukuba, Tsukuba, Ibaraki, Japan

Masahide Kondo,

• Watanabe, Tsuyoshi, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan

Tsuyoshi Watanabe,

• Tsuruya, Kazuhiko, Nara Medical University, Kashihara, Nara, Japan

Kazuhiko Tsuruya,

Background

Dyslipidemia is a significant risk factor of CVD and seems to be associated with CKD onset and progression. On the contrary, CKD patients have dyslipidemia more frequently than non-CKD patients, but it is unclear whether CKD affects new onset of dyslipidemia.

Methods

This is a longitudinal study based on data obtained from the Japanese Specific Health Check and Guidance System. Among 664,926 individuals who participated in this program from 2008 to 2014, we excluded participants who met the following criteria: 1) health check only one time, 2) missing values for creatinine or proteinuria, 3) dyslipidemia at baseline, or 4) medication for dyslipidemia at any point. We evaluated new onset of dyslipidemia according to each factor; hypertriglyceridemia (High-TG), hyper-LDL cholesterolemia (High-LDL), or hypo-HDL cholesterolemia (Low-HDL), defined as triglycerides ≥150 mg/dL, LDL cholesterol ≥140 mg/dL, or HDL cholesterol <40 mg/dL, respectively, and compared between participants with and without CKD. These associations were analyzed using Kaplan-Meier methods and Cox regression analysis after adjustment for clinically relevant factors.

Results

During a median follow-up period of 3.1 years, the cumulative incidences of High-TG, High-LDL, and Low-HDL were 45,300, 51,940, and 13,313 participants, respectively, among 305,893 participants (non-CKD: 254,884; CKD: 51,009). In the univariable analyses, hazard ratios (HRs) [95% confidence intervals (CIs)] in CKD vs non-CKD participants were 1.31 [1.27-1.34], 1.02 [0.99-1.05], and 1.70 [1.63-1.77] for High-TG, High-LDL, and Low-HDL, respectively. After adjustment for clinically relevant confounders, adjusted HRs [95% CIs] in CKD participants were 1.10 [1.07-1.13], 0.99 [0.96-1.02], and 1.16 [1.11-1.22] for High-TG, High-LDL, and Low-HDL, respectively.

Conclusion

CKD was associated with new onset of High-TG and Low-HDL, but not High-LDL among general population in Japan.