Abstract: PO1343
Effect of Hemodialysis Vascular Access Type on Serum Interleukin-6 (IL-6) Levels in ESRD
Session Information
- Vascular Access
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 704 Dialysis: Vascular Access
Authors
- Aggarwal (Gupta), Monika, Hunter Holmes McGuire VA Medical Center, Richmond, Virginia, United States
- Feldman, George M., Hunter Holmes McGuire VA Medical Center, Richmond, Virginia, United States
- Samuel, Naveen, Hunter Holmes McGuire VA Medical Center, Richmond, Virginia, United States
- Retnam, Reuben P., Virginia Commonwealth University, Richmond, Virginia, United States
- Bandyopadhyay, Dipankar, Virginia Commonwealth University, Richmond, Virginia, United States
- Ghosh, Shobha, Hunter Holmes McGuire VA Medical Center, Richmond, Virginia, United States
Background
Chronic inflammation is prevalent and associated with poor outcomes in end stage renal disease(ESRD),and may be related to underlying comorbid conditions like diabetes mellitus.It is unclear if dialysis vascular access type may affect inflammation. We evaluated the effect of hemodialysis vascular access type on serum IL-6 level.
Methods
15 patients with ESRD on chronic maintenance hemodialysis at McGuire Hunter Holmes VAMC were enrolled. Blood samples were drawn at 0 ,30, 60, 90, 120, 180, and 240 minutes after starting dialysis. Serum IL-6 was measured using ELISA.Data were analyzed using t-test and is presented as Mean+SD.
Results
6 patients had catheter (mean age 71.3+3.3 years), and 9 (mean age 64.5+4 years) had AV access . All were male. 5 patients in each group were African-American. 2 patients with catheter and 7 patients with AV access had diabetes.IL-6 level was higher at all time points(statistically significant) in patients with catheter compared to patients with AV access (Fig 1. and Table 1.)
Conclusion
ESRD patients with catheters had higher serum IL-6 levels compared to AV access inspite of lower proportion of diabetics. Catheters may contribute to inflammation, which may partly explain worse outcomes seen with catheters.
Table 1.IL-6 Level at different time points (Mean+/-SD)
| Time Point (Minutes) | AV access | Catheter | P value |
| 0 | 2.87+/-1.53 | 11.96+/-9.47 | 0.009 |
| 30 | 2.1+/-1.14 | 11.29+/-10.29 | 0.011 |
| 60 | 2.75+/-1.53 | 11.6+/-8.92 | 0.004 |
| 90 | 3.15+/-1.51 | 12.32+/-9.42 | 0.006 |
| 120 | 3.14+/-1.65 | 13.11+/-9.53 | 0.003 |
| 180 | 3.32+/-1.57 | 13.76+/-9.75 | 0.003 |
| 240 | 3.27+/-1.26 | 14.8+/-11.08 | 0.003 |
Fig1. IL-6 levels by Type of Vascular Access .
Funding
- Veterans Affairs Support