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Kidney Week

Abstract: PO2053

Insulin Resistance and Pancreatic Beta-Cell Function in Calcium Kidney Stone Formers

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1300 Health Maintenance, Nutrition, and Metabolism

Authors

  • Tang, Olive W., Johns Hopkins Medicine, Baltimore, Maryland, United States
  • Mitchell, Kevin, Alpert Medical School of Brown University, Providence, Rhode Island, United States
  • Tang, Jie, Alpert Medical School of Brown University, Providence, Rhode Island, United States
Background

Diabetes mellitus is common among individuals with kidney stones; however, the risk factors associated with glucose dysregulation in this population is unclear.

Methods

We characterized the independent associations between vitamin D, urinary measures of dietary intake (sodium, magnesium), and urinary ammonia and citrate with homeostasis model assessment of β-cell (HOMA-B) and insulin resistance (HOMA-IR) in prevalent calcium kidney stone formers without diabetes mellitus recruited from Lifespan Kidney Stone Clinic (N = 96). We used linear regression with adjustment for demographics, body mass index, hypertension, hyperlipidemia, parathyroid hormone, and serum uric acid.

Results

The study population had a mean age of 53 years, 48% were male, and 83% were Caucasian. The mean 25-hydroxy-vitamin D (25D) was 30 ng/ml, 1,25-dihydroxy-vitmain D (1,25D) was 55 pg/ml, 24-hour urine sodium was 145 mmol, urine ammonia was 30 mEq, urine citrate was 590 mg, and urine magnesium was 102 mg. Mean HOMA-B was 172.1, and mean HOMA-IR was 5.4. Urine sodium was negatively associated with HOMA-B, but not HOMA-IR. Urine ammonia was positively associated with HOMA-IR, but not HOMA-B. Urine citrate was positively associated with both HOMA-B and HOMA-IR (Table).

Conclusion

In our cohort of calcium kidney stone formers, high salt intake and low urine citrate were associated with worse beta-cell function. High urine ammonia and citrate were associated with increased insulin resistance.

Funding

  • Clinical Revenue Support