ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on X

Kidney Week

Please note that you are viewing an archived section from 2020 and some content may be unavailable. To unlock all content for 2020, please visit the archives.

Abstract: PO0494

Relationship Between Renal Function and Quality of Life in Patients with CKD at the Pre-Dialysis Stage

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Nakamura, Hironori, Department of nephrology, Shinonoi General Hospital, Nagano, Japan
  • Murakami, Minoru, Department of Nephrology, Saku Central Hospital, Saku, Japan
  • Mariko, Anayama, Department of nephrology, Shinonoi General Hospital, Nagano, Japan
  • Kurihara, Shigekazu, Department of nephrology, Shinonoi General Hospital, Nagano, Japan
  • Makino, Yasushi, Department of nephrology, Shinonoi General Hospital, Nagano, Japan
  • Nagasawa, Masaki, Department of nephrology, Shinonoi General Hospital, Nagano, Japan
  • Kashihara, Naoki, REACH-J Steering committee, Tukuba, Japan
  • Yamagata, Kunihiro, REACH-J Steering committee, Tukuba, Japan
  • Wada, Takashi, REACH-J Steering committee, Tukuba, Japan
  • Narita, Ichiei, REACH-J Steering committee, Tukuba, Japan
  • Okada, Hirokazu, REACH-J Steering committee, Tukuba, Japan
Background

There have been several studies evaluating the effect of kidney function on health-related quality of life (HRQOL). However, the association between kidney function and the burden of kidney disease, symptoms, and the effects of kidney disease among patients with advanced-stage kidney disease remains unclear.

Methods

The nationwide prospective Reach-J cohort study was successfully conducted. Of these patients, 2,248 with advanced chronic kidney disease (CKD) stage G3b (n = 632), G4 (n = 1010), and G5 (n = 606) were included in our study. A questionnaire regarding the kidney-disease-specific domains of quality of life (QOL) including burden, symptoms, and the effects of kidney disease at the baseline was cross-sectionally evaluated. Moreover, factors influencing the QOL were studied.

Results

Patients’ characteristics were as follows: age, 69.1±12.6 years; male, 64.6%; estimated glomerular filtration rate, 23.2 ± 10.4 mL/min/1.73m2; and serum creatinine level was 2.64 ± 1.49 mg/dL. The rates of comorbidities were as follows: diabetes, 33.6%; hypertension, 87.3%; ischemic heart disease, 8.2%; and chronic obstructive pulmonary disease (COPD), 2.3%. Crude scores in CKDG4 and CKDG5 as comparison to CKDG3b were as follows: burdens, -8.7 and -17.5; symptoms; -2.1 and -4.5; effects of kidney disease, -4.4 and -8.1, respectively. After adjusting for age, sex, body mass index (BMI), diabetes, hypertension, ischemic heart disease, COPD, and CKD stage; multivariate analysis to identify independent factors that caused reduced QOL scores revealed that age (β = 0.053, p = 0.024), BMI (β = 0.091, p < 0.001), diabetes (β = −0.058, p = 0.014), and CKD stage (β = −0.25, p < 0.001) were significant factors for burden; that age (β =−0.153, p < 0.001), diabetes (β =−0.093, p < 0.001), and CKD stage (β =−0.11, p < 0.001) were significant factors for symptoms; and that age (β = −0.128, p < 0.001), BMI (β = 0.067, p = 0.005), diabetes (β = −0.066, p = 0.006) and CKD stage (β = −0.196, p < 0.001) were significant factors for the effects of kidney disease.

Conclusion

This study suggests that the progression of CKD stage could be associated with a reduction in some aspects of HRQOL in advanced-stage CKD patients.