Abstract: PO0685
Characteristics and Outcome of AKI Needing Dialysis with COVID-19 Infection
Session Information
- COVID-19: AKI and Outcomes
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Coronavirus (COVID-19)
- 000 Coronavirus (COVID-19)
Authors
- Sankarasubbaiyan, Suresh, Nephroplus, Hyerabad, Telengana, India
- Gowda, Mallikarjuna Gowda Bg, Nephroplus, Hyerabad, Telengana, India
- Ganapathi Subraman, Venkatraman, Nephroplus, Hyerabad, Telengana, India
- Husain, Mohammad Sarwar, Nephroplus, Hyerabad, Telengana, India
- Sonawane, Vikram Ashok, Nephroplus, Hyerabad, Telengana, India
- Puvvada, Satyanarayana Rajesh, Nephroplus, Hyerabad, Telengana, India
- Kumar, Kaparaboina Kartheek, Nephroplus, Hyerabad, Telengana, India
- Venkata, Guruvulu, Nephroplus, Hyerabad, Telengana, India
- Shah, Kamal D., Nephroplus, Hyerabad, Telengana, India
Background
COVID-19 infection has varying grades of mortality worldwide. Multi-organ injury, not uncommonly associated with AKI, portends a poor outcome. We studied AKI needing hemodialysis (HD) in the context of COVID-19 infection
Methods
From March 15th to May 25th 2020, for consecutive COVID-19 infections AKI needing HD in a large dialysis network age, gender, payer type, days:admission to HD start, urine output, S. Cr, comorbidities, other organ injuries, length of stay & outcome , dialysis session details: blood flow rate(BFR), dialysis flow rate(DFR), ultafiltration volume were reviewed. We compared survivors and non survivors using Mann Whitney/Wilcoxon 2 sample test for medians and Fisher exact 2 tailed for association
Results
n = 20. Mean age: 56. 7 + 3.93 years. M:F 17:3, 9 survived, 11 expired. HD sessions=51; CRRT: 4, duration: 29.2 + 25.4 hours. 47 sessions: Duration: 4.87 + 1.11 hours, BFR: 195 + 43 ml/min, DFR: 389 +99 ml/mn, UF: 437ml/hour. No clotting reported.
Conclusion
AKI needing HD in COVID-19 infection is associated with significant multiorgan injury and high mortality; middle aged male predominate. No significant clinical characteristics were predictive of survival in a sample size
Comparison of survivors and non survivors of COVID-AKI needing HD
| Survivors (n= 9) | Non survivors (n=11) | p value | |
| Age (yrs) | 56 | 55 | 0.68 |
| M/F (%) | 88.9/11/.1 | 81.8/18.2 | 1.0 |
| Self pay or private Insurance/public Insurance (%) | 77.7/22.2 | 81.8/18.2 | |
| Htn (%) | 33.3 | 27.3 | 1.0 |
| DM (%) | 11.1 | 36.4 | .31 |
| Altered Mentation | 88.9% | 63.6 | .32 |
| Vasopressor use (%) | 22.2 | 45.5 | .37 |
| Ventilator (%) | 47.37 | 52.63 | 1.0 |
| Admission to HD start interval (days) | 2 | 1 | 0.87 |
| Oliguria (%) | 88.9 | 90.9 | 1.0 |
| S. Creatinine (mg%) | 6.16 | 3.00 | 0.09 |
| No of HD | 2 | 2 | 0.65 |
| Hb (g%) | 9.6 | 10.8 | .17 |
| TC (/MM3) | 9878 ± 4950 | 23962 ± 22221 | |
| Hospital stay (days) | 24 | 13 | .60 |
| Antivirals Rx (%) | 66.7% | 90.9% | .28 |
| Steroid Rx (%) | 66.7% | 81.8% | .61 |