Abstract: PO2295
FCGG Renal Biopsy Network: First Epidemiological Report on Pediatric Renal Disease
Session Information
- Pediatric Nephrology: Benign Urology, AKI, Neonatal Nephrology, and Case Reports
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Pediatric Nephrology
- 1700 Pediatric Nephrology
Authors
- Knops, Noel, Katholieke Universiteit Leuven Universitaire Ziekenhuizen Leuven Campus Gasthuisberg, Leuven, Flanders, Belgium
- De Meester, Johan MJ, AZ Nikolaas, Sint-Niklaas, Oost-Vlaanderen, Belgium
- Dendooven, Amélie, Universitair Ziekenhuis Gent, Gent, Oost-Vlaanderen, Belgium
- Laurens, Wim, AZ Nikolaas, Sint-Niklaas, Oost-Vlaanderen, Belgium
- Sprangers, Ben, Katholieke Universiteit Leuven Universitaire Ziekenhuizen Leuven Campus Gasthuisberg, Leuven, Flanders, Belgium
- Levtchenko, Elena N., Katholieke Universiteit Leuven Universitaire Ziekenhuizen Leuven Campus Gasthuisberg, Leuven, Flanders, Belgium
Background
In 2016, a regional renal biopsy network was founded as a collaboration between renal pathologists and nephrologists in order to standardize diagnosis and therapy. Uniform renal biopsy request and renal biopsy report forms were introduced, together with a new comprehensive list of renal pathology diagnoses for coding purposes. The 2017-2018 epidemiological data of the pediatric patients (age 0-17 years) are presented.
Methods
Following informed consent and in compliance with GDPR, data registration consists of basic patient and categorical renal data, semi-structured medical information of renal disease, structured information of renal histopathology, and the clinical renal disease.
Results
In 2017 and 2018, 92 renal biopsies were performed in pediatric patients (age = 0-17 years) or 3.6 per 100,000 pediatric inhabitants per year. Three clinical patterns were equally represented: only proteinuria >1g/day; only hematuria; and combination of proteinuria and hematuria. Acute or chronic renal failure were rare. In the youngest age group (0-5 years; N=26) minimal change disease predominated, followed by Henoch-Schönlein nephritis. The middle age group (6-11 years; N=32) mainly presented with diseases characterized by hematuria: IgA nephropathy, Henoch-Schönlein nephritis and Alport’s disease. A more diverse renal disease spectrum was present in the highest age group (12-18 years; N=34): IgA nephropathy, different forms of proliferative glomerulonephritis and of nephrotic syndrome of childhood. Patients with a Caucasian descent presented with IgA nephropathy, while a nephrotic syndrome was more common in those without a Caucasian descent. Alport’s disease was particularly diagnosed in female patients, IgA nephropathy in male patients, and the gender distribution was equal in minimal change disease.
Conclusion
The FCGG network provides a better cross-talk between renal pathologists and nephrologists. For the first time, reliable estimates of pediatric renal diseases based on histology are available; genetic analyses are not yet included. Efforts to coordinate clinical care of pediatric renal diseases in the region are ongoing.