Abstract: PO2474
Renal Transplant Recipients Suffer Significantly More Complications After Breast Cancer Surgery but Benefit from Treatment at Transplant Centers
Session Information
- Transplant Complications: Infection
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 1902 Transplantation: Clinical
Authors
- Choubey, Ankur P., The University of Toledo Medical Center, Toledo, Ohio, United States
- Parsikia, Afshin, Westchester Medical Center, Valhalla, New York, United States
- Castaldi, Maria, Westchester Medical Center, Valhalla, New York, United States
- Latifi, Rifat, Westchester Medical Center, Valhalla, New York, United States
- Ortiz, Jorge, The University of Toledo Medical Center, Toledo, Ohio, United States
Background
Breast Carcinoma has the highest incidence of any cancer in adult females. The impact of kidney transplant (KT) on breast cancer surgery has not been examined. Our objective was to evaluate the influence of a previous KT on the short-term outcomes of mastectomy or lumpectomy.
Methods
A retrospective analysis was conducted using Nationwide Inpatient Sample (NIS) data between 2005 and 2014. Population included adult females with kidney transplant surgically treated for breast malignancy. Weighted multivariate regression models were employed to compare outcomes at transplant and non-transplant centers.
Results
398 women met the inclusion criteria. There was a greater proportion of African-American (p<0.001), and Hispanic women (p=0.01) compared to the cohort. KT recipients had more comorbidities and higher Elixhauser Comorbidity Index scores (p<0.001). We noted longer length of stay (p<0.001), higher expenditure (p=0.001), and complications (p<0.001). Specifically, rates of hematomas (p=0.041), acute renal failure (p<0.001), blood transfusion (p<0.001), fresh frozen plasma transfusion (p<0.001), cardiovascular (p<001), and other complications (p=0.012) were increased. There was no mortality among transplant recipients.
Weighted multivariate analyses highlight that rates of complication (p=0.040), and length of stay (p<0.001) are lower at transplant centers.
Conclusion
History of kidney transplant has a significant impact on the outcomes of mastectomy or lumpectomy. These patients suffer more post-operative adverse events. However, KT recipients experience superior outcomes at transplant centers.
Table 1. Patient Demographics, Outcomes, and Adjusted Outcomes for Kidney Transplant Recipients Treated at Transplant Centers.