Abstract: PO0993
Self-Management and Progression of Patients with Diabetic Kidney Disease (DKD): A Retrospective Cohort Study
Session Information
- Diabetic Kidney Disease: Clinical - 1
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Diabetic Kidney Disease
- 602 Diabetic Kidney Disease: Clinical
Authors
- Wu, Yifan, Renal Division, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, China
- Wang, Ping, Department of Internal Medicine, Yunfu hospital of Chinese medicine, Yunfu, China
- Luo, Li, The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- Zhang, Min, The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- Xia, Bingqing, The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- Fu, Lizhe, Chronic Disease Management Outpatient, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- Tang, Fang, Chronic Disease Management Outpatient, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- Zhang, Xianlong, The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- Liu, Xusheng, Renal Division, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, China
- Lu, Fuhua, Renal Division, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, China
Background
Few specifics were proved effective to delay DKD progression while accumulating evidence supported potential merits of self-management on it. This study aimed to evaluate the association between self-management and progression of non-dialysis CKD3-5 DKD patients.
Methods
Data including demographics, procedure notes, laboratory findings, and medication of the included cohort were analyzed. The cohort was divided into self-management group and control group based on previous self-management exposure. The between-group comparison of renal function at 2 years and survival analysis were conducted.
Results
Total 92 patients were included(47 in self-management group and 45 in control group). Declined serum creatinine level and preserved eGFR were detected in self-management group after 2 years both with no significant difference(P =0.695，0.922), while significantly higher serum creatinine level(P=0.010) and decreased eGFR with no evident significance(P =0.059) after 2 years were found in control group. We defined eGFR＜5ml/min/1.73 m2, initiation of renal replacement therapy and death as composite endpoints, and performed time-to-event survival analysis. Ten endpoint events in self-management group(mean survival time 221.31±12.97 weeks) and 17 in control group(mean survival time 168.63±15.03 weeks) were recorded, with significant difference between group comparison(χ2=6.319，P =0.012). Further Cox proportional hazards regression with three adjusted models showed that self-management engagement was an independent factor associated with reduced risk of incident endpoints.
Conclusion
The findings documented predisposing preserved renal function of patients with self-management at 2 years and self-management engagement as an independent factor for decreased risk of endpoints, indicating its potential benefits on delaying DKD progression.