Abstract: PO0437
Increased Risk of Progression to ESRD or Death in CKD Patients with Symptoms of Depression: A Systematic Review and Meta-Analysis of Cohort Studies
Session Information
- CKD Epidemiology, Biomarkers, Predictors
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Zeng, Jiahao, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- Qin, Xindong, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China, Guangzhou, China
- Liu, Xusheng, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China, Guangzhou, China
Background
Comorbid symptoms of depression are common psychiatric disorder in patients with chronic kidney disease (CKD). It remains unclear whether it is an independent risk factor for progression of patients with CKD not requiring dialysis. We conducted a systematic review to assess the association of depressive symptoms with poor clinical outcomes in patients with CKD not requiring dialysis.
Methods
PubMed, Embase and CINAHL were searched (up to February 15th, 2020) for cohort studies assessing the association of depression with progression to end-stage renal disease (ESRD), defined as requiring maintenance dialysis, or all-cause mortality in patients with CKD not requiring maintenance dialysis. Two independent researchers extracted data, assessed risk of bias and evidence certainty.
Results
Seven cohort studies of 6145 patients were included. Methodological quality of studies was generally low risk of bias. Compared with non-depression or low depressive symptoms, high depressive symptoms increased the risk of progression to ESRD (HR, 2.09 95%CI 1.43 to 3.07, I2=37%), all-cause mortality (HR, 1.51 95%CI 1.13 to 2.01, I2=57%) and hospitalization (HR, 1.52 95%CI 1.20 to 1.93, I2=32%).
Conclusion
Depressive symptoms in CKD are independent risk factors of poor clinical outcomes, including ESRD, all-cause death, and hospitalization. There is necessary to design high quality studies to assess the effects of treating depressive symptoms in patients with CKD.